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Enzymes in Drug Manufacturing
Business Insights, March 2011, Pages: 128
Biocatalysis in pharmaceutical manufacturing is being driven by advances in enzyme and genomics technologies that are increasing the breadth of reaction applicability. The environmental benefits of enzymatic catalysis are also a strong influence.
This report examines the benefits and challenges of implementing enzymatic steps in pharmaceutical manufacturing. It covers why enzymes are central to green chemistry and industrial biotechnology.The range of industrial enzymes and sources of innovation are covered, along with numerous case studies of enzymes being successfully employed.
Scope of this research
- Understand why biocatalysis plays a central role in the emerging trend toward green chemistry.
- Appreciate the power of enzymes in controlling the formation of chiral products.
- Learn of the techniques employed to develop non-natural enzymes that are better suited to industrial processes.
- Examine case studies in which enzymes have provided significant benefits during process development and optimization efforts. Identify the likely sources of future advances in developing novel enzymatic catalysis processes.
Research and analysis highlights
Enzymes can replace conventional catalysts in drug manufacturing and give significant gains in terms of reduced raw materials and other inputs by improving efficiency and allowing reactions to take place under milder conditions. Biocatalytic steps often offer a powerful solution to the problem of controlling stereochemistry.
Both green chemistry and industrial biotechnology are important emerging trends worldwide. Enzymes are central to both disciplines so developments are likely to increase the focus on biocatalysis and encourage its wider implementation within industry.
There are many potential sources of innovative enzymes that could meet the needs of pharma. These include organisms from extreme environments and genomic databases. New and old enzymes can be optimized for their properties using technologies such as directed evolution.
Key reasons to purchase this research
- What benefits do enzymes offer compared with conventional chemical synthesis?
- How can an enzymatic steps be integrated into an existing manufacturing process and what are the challenges in so doing?
- Why are enzymes such a key focus in both green chemistry and industrial biotechnology?
- How can a natural enzyme be modified so that its properties are compatible with process conditions typically found in the pharmaceutical industry?
- What sectors of industry currently make the best use of enzymes in their processes and can pharma follow suit?
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