Hyaluronan in Cancer Biology

Table of Contents

Preface: Hyaluronan and Cancer
Robert Stern

Section I: Historical Overview

1.Association between "acid mucopolysaccharides” and malignancy: an old
concept comes of age, finally
Robert Stern

Section II: Cell Biology of Hyaluronan in Cancer

2.Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells
Mark G. Slomiany and Bryan P. Toole

3.Growth factor regulation of hyaluronan deposition in malignancies
Paraskevi Heldin, Eugenia Karousou, and Spyros S. Skandalis

4.HYALURONAN BINDING PROTEIN 1 (HABP1) IN CANCER BIOLOGY
Kasturi Datta

Section III: Hyaluronan Receptors and Signal Transduction Pathways

5.CD44 meets merlin and ezrin: Their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of merlin
Ivan Stamenkovic and Qin Yu6.Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation and tumor progression
Lilly Y.W. Bourguignon

7.Adhesion and penetration: two sides of CD44 signal transduction cascades in the context of cancer cell metastasis
David J.J. Waugh, Ashleigh McClatchey, Nicola Montgomery, and Suzanne McFarlane

8.INVOLVEMENT OF CD44, A MOLECULE WITH A THOUSAND FACES, IN CANCER DISSEMINATION
David Naor, Shulamit B. Wallach-Dayan, Muayad A. Zahalka, and Ronit Vogt Sionov

9.Rhamm/Hmmr: an intinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation.
James B. McCarthy and Eva A. TurleySection IV: Hyaluronan Synthesis

10.Altered hyaluronan biosynthesis in cancer progression
Naoki Itano and Koji Kimata

Section V: Hyaluronan Degradation, the Hyaluronidases, and the Products of Degradation

11.HYALURONDIASE: BOTH A TUMOR PROMOTER AND SUPPRESSOR
Vinata B. Lokeshwar and Marie G. Selzer

12.The hyaluronidases in cancer biology
Robert Stern

13.Hyaluronan fragments: informational polymers commandeered by cancers
Kazuki N. Sugahara

Section VI : Hyaluronan in Cancer Epithelial-Stromal Interactions

14.Hyaluronan in human tumors: importance of stromal and cancer cell-associated hyaluronan
Raija H. Tammi , Anne H. Kultti, Veli-Matti Kosma, Risto Pirinen, Päivi Auvinen, and Markku I. Tammi

15.THE ONCOFETAL PARADIGM REVISITED: MSF AND HA AS CONTEXTUAL DRIVERS OF CANCER PROGRESSION
Seth L. Schor, Ana M. Schor, Ian R. Ellis, Sarah J. Jones, Margaret Florence, Jacqueline Cox, and Anne-Marie Woolston

Section VII: Hyaluronan and Individual Cancers

16.Hyaluronan synthesis and turnover in prostate cancer
Melanie A. Simpson

17.Role of hyaluronan in melanoma progression
Carl Gebhardt, Marco Averbeck, Ulf Anderegg, and Jan C. Simon

18.Role of Hyaluronan metabolism in the initiation, invasion and metastasis of Breast cancer
Tracey J. Brown and Natalie Thomas

Section VIII: Clinical Uses of Hyaluronan-Related Biomaterials as Anti-Cancer Agents

19. Clinical application of hyaluronidase in combination cancer chemotherapy: a historic perspective
Gerhard Baumgartner and Gerhard Hamilton

20.Exploring the hyaluronan-CD44 interaction for cancer therapy
Virginia M. Platt and Francis C. Szoka

Section IX: A New Perspective

21.Hyaluronidase-2 and its role as a cell-entry receptor for sheep
retroviruses that cause contagious respiratory tract cancers
A. Dusty Miller

Authors

Robert Stern Emeritus, Department of Pathology, School of Medicine, University of California, San Francisco, USA. Robert Stern, MD, is Emeritus Professor, Department of Pathology, School of Medicine, University of California, San Francisco. Robert Stern left Germany in 1938 for Seattle, Washington. He graduated from Harvard College in 1957, and obtained the M.D. degree from the University of Washington (Seattle) in 1962, followed by a rotating internship at King County Hospital (Seattle). While a medical student, he worked in the laboratories of Drs. Krebs and Fisher, who became Nobel laureates. He received his resident training in Anatomic Pathology at the NCI, and was a research scientist at the NIH for 10 years. Since 1977, he has been a member of the Pathology Department at the University of California, San Francisco. He is a board-certified Anatomic Pathologist, participating in the research, teaching, administrative, and diagnostic activities of the Department. He directed the Ph.D. program in Experimental Pathology for ten years. For the past decade, his research has focused on hyaluronan and the hyaluronidases, an outgrowth of an interest in malignancies of connective tissue, stromal-epithelial interactions in cancer, and biology of the tumor extracellular matrix. His laboratory was the first to identify the family of six hyaluronidase sequences in the human genome. These enzymes were then sequenced, expressed, and characterized in his laboratory. Subsequent work has identified a catabolic pathway for hyaluronan.