Natural Killer Cells
Elsevier Science and Technology, November 2009
The Natural Killer [NK] Cell plays a critical role in regulating the innate and adaptive immune response to pathogens, injury and stress. Although originally portrayed as primarily a lytic cell, the NK cell has emerged as a cell capable of helper function, expansion, contraction, and accelerated memory responses - features similar to other adaptive immune cells. It is a professional accelerator of immunity, mediating dendritic cell maturation and its precursors critical for the origin and development of secondary lymph node structures. NK cells also play an essential role in mammalian placentation by regulating the quality of blood supply to the growing fetus. These characteristics place the NK cell in a unique position, with a major role in sculpting the host response to damage and injury. This volume is the first complete and authoritative reference to explore these emergent, exciting aspects of the NK cell, placing it at the center of damage/danger recognition and the response to stress. Natural Killer Cells details NK cell biology, the role of NK cells in regulating immunity through interactions with other cells and tissues, the participation of NK cells in disease and special topics in NK biology.
- Provides a broad, detailed canvas for students, fellows, scientists, and practitioners
- Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
- Image database included in companion website
I. NK BIOLOGY
Developmental Stages and Pathways of NK Cell Maturation
Developmental Origins of Thymus-Derived Natural Killer Cells
Interferon-Producing Killer Dendritic Cells (IKDC)
Natural Killer Cells in Cancer
NK Cell Immune Recognition: NKG2D Ligands and Stressed Cells
NK Cell KIR Heterogeneity and Evolution
Signaling Events in Natural Killer Cells
Human Natural Killer Cell Development
II. NK INTERACTIONS WITH OTHER CELLS
Isolation, Culture and Propagation of Natural Killer (NK) Cells
The Localization and Migration of Natural Killer Cells in Health and Disease
Receptors on NK Cells
Development and Testing of NK Cell Lines
NK Cell-derived Cytokines and Delivery
NK Cell Synapses
NK Cells as Recipients of Cytokine Signals
NK Cells and Chemokines
Natural Killer Cytolytic Activity
Illuminating Intranodal Natural Killer Cell Behavior Using Two-Photon Microscopy
Dendritic Cells and NK Cells
NK and NKT cells: The Innate- Adaptive Interface Including Humoral Responses
NK Cell and Endothelial Cell Interactions
NK Cell/Epithelial Interactions
NK Cell-T Cell Interactions
III. NK CELLS IN THE TISSUES
NK Cells and NKT Cells in Cutaneous Disorders
Natural Killer Cells in the Respiratory Tract
Intestinal Natural Killer Cells
Natural Killer Cells in the Liver
Natural Killer Cells in the Spleen and Lymph Node
Natural Killer Cells in the Central Nervous System
NK Cells in the Eye
NK Cells and Reproduction
Identification of Natural Killer Cells in Tissues and Their Isolation
NK Cell Immune Regulation: Coordination of Immune Function in Tissues
IV. NK CELLS IN DISEASE
Natural Killer Cells and Transplantation
Natural Killer Cells and Autoimmunity
Interaction of NK Cells with Bacteria
Natural Killer Cells and Human Immunodeficiency Virus
Cytomegalovirus Infection and NK Cells
Natural Killer Cells in Allergy
Natural Killer Cells in Wound Healing
Natural Killer Cells in Atherosclerosis
Natural Killer Cells in Leukemia
Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation
Clinical Trials of NK Cells for Cancer
Natural Killer Cells and Hepatitis C Virus Infection
Natural Killer Cells and the Biology of Parasitism
Lymphoproliferative Disorders of Natural Killer Cells
V. SPECIAL TOPICS IN NK BIOLOGY
Natural Killer Cell Induction of Tolerance
Genetic Engineering of Natural Killer Cells
NK Cell-Mediated Target Cell Death
NK-Cell Tracking Using Non-Invasive Imaging Modalities
Lotze, Michael T.
Thomson, Angus W.
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