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Origin and Evolution of Viruses. Edition No. 2

  • ID: 1769117
  • Book
  • June 2008
  • 560 Pages
  • Elsevier Science and Technology
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New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.

- NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution
- UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups
- SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
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Origins and widespread evolutionary significance of viruses; Nature and evolution of early replicons; Structure and evolution of viroids; Mutation, competition and selection as measured with small RNA molecules; Viral quasispecies, fitness variations and error;Phylogenetic analysis of viral sequences: principles and applications; Evolution of functional protein motifs in RNA viruses; Copying fidelity of viral and cellular polymerases; RNA interference and its evolutionary implications; Phage models of virus adaptation and evolution; Genomic analysis and evolution of large bacteriophages; Plant virus evolution: past, present and future; Mutant clouds and bottleneck events in plant virus evolution; Retrovirus evolution and pathogenesis; HIV population dynamics and drug treatments; The impact of rapid evolution of hepatitis viruses; Evolution of animal and human influenza viruses; Evolution and emergence of arboviruses; Parvovirus variation and evolution: impact on disease emergence; Genome diversity and evolution of human papillomaviruses; Poxvirus diversity and evolution; The molecular evolutionary history of the herpesviruses; Cellular functions involved in virual hypermutagenesis.
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Domingo, Esteban
Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.
Parrish, Colin R.
Holland, John J.
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