New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.
NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution
UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups
SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Origins and widespread evolutionary significance of viruses
Nature and evolution of early replicons
Structure and evolution of viroids
Mutation, competition and selection as measured with small RNA molecules
Viral quasispecies, fitness variations and error;Phylogenetic analysis of viral sequences: principles and applications
Evolution of functional protein motifs in RNA viruses
Copying fidelity of viral and cellular polymerases
RNA interference and its evolutionary implications
Phage models of virus adaptation and evolution
Genomic analysis and evolution of large bacteriophages
Plant virus evolution: past, present and future
Mutant clouds and bottleneck events in plant virus evolution
Retrovirus evolution and pathogenesis
HIV population dynamics and drug treatments
The impact of rapid evolution of hepatitis viruses
Evolution of animal and human influenza viruses
Evolution and emergence of arboviruses
Parvovirus variation and evolution: impact on disease emergence
Genome diversity and evolution of human papillomaviruses
Poxvirus diversity and evolution
The molecular evolutionary history of the herpesviruses
Cellular functions involved in virual hypermutagenesis.
Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.
Parrish, Colin R.
Holland, John J.