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Osteoimmunology. Interactions of the Immune and Skeletal Systems
Elsevier Science and Technology, September 2010, Pages: 470
Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. It has become increasingly clear that critical interactions between these two organ systems frequently occur. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. However, because these two disciplines developed independently, investigators in each don't always fully appreciate the significance of the other. This book is meant to provide a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated.
The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. Approximately half the book will focus on the role that osteoimmunology plays in the development of human diseases.
This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology - all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact. The book will be written at the level of a graduate school text. It will be easily readable by someone with a college level understanding of biologic science. However, it will contain details that will make it appealing to researchers in any of the relevant areas who want to fully understand the role that interactions between the bone and immune system play in the responses that they are studying.
Pharmaceutical companies are very interested in this topic as it represents a new area for the design of drug targets. The recent development of an antibody therapy against RANK ligand, which was originally identified as a regulator of immune cells, but is now know to also regulate bone resorption, is one example of how research in osteoimmunology can be used to develop a drug.
- Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work
- Experts in bone biology and immunology (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.
- Clear presentations by bone biologists of the cellular and molecular mechanisms underlying bone cell development leading to bone and immunological diseases such as Lupus
- Clear presentations by immunologists of how immune cells develop and how the immune system plays a role in bone diseases like osteoporosis and arthritis
Overview: The developing Field of Osteoimmunology
Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo
The Origins of Bone Cells: Osteoclasts
G. David Roodman, Deborah L. Galson
Adaptive Immune Response
David G. Hesslein, Hector L. Aguila, Mark C. Horowitz
The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche
Henry Kronenberg, Joy Wu
The Signaling Pathways Regulating Osteoblast Differentiation
Jane Lian, Gary Stein
The Signaling Pathways Regulating Osteoclast Differentiation
Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi
The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells
Interactions of Osteoblasts and Osteoclasts
T. John Martin, Natalie A. Sims, Julian M. W. Quinn
The Role of the Immune System in the Development of Osteoporosis
Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder
The Role of the Immune System in the Bone Loss of Inflammatory Arthritis
Georg Schett, Steven Goldring
The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease
Francisco Sylvester, Anthony T. Vella
The Role of the Immune System in Fracture Healing
Louis Gerstenfeld, Thomas Einhorn, Brandon Steen
The Role of the Immune System in the Development of Chronic Infections of Bone
Brendan Boyce, Edward Schwarz, Lianping Xing
The Role of the Immune System in Hematologic Malignancies, which Affect Bone
Gregory Mundy, Claire M. Edwards, Jessica Fowler
The Role of the Immune System in Dental Disease
Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet
Dr. Lorenzo is Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center. He is a nationally renowned expert on bone remodeling and its effect on bone health.
Dr. Choi is Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA.
Dr. Horowitz is Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine. His research interests include the interactions between the skeletal, immune, and hematopoietic systems as they relate to normal and pathologic bone remodeling.
Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and interactions between immune and bone systems.