- Language: English
- 128 Pages
- Published: March 2010
- Region: Global
Pharmaceutical Inhalation Aerosol Technology, Second Edition. Drugs and the Pharmaceutical Sciences
- Published: September 2003
- Region: Global
- 288 Pages
- Informa Healthcare
This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.
Factors governing aerosol deposition and targeting in the lung: physiology of the airways, Anthony J. Hickey and David C. Thompson; pharmacology of therapeutic aerosols, David C. Thompson; targeting by deposition, Igor Gonda; drug targeting to the lung - chemical and biochemical considerations, Peter A. Crooks; lung deposition simulation, Warren Finlay; lung deposition imaging, Myrna Dolovich; pharmacokinetics and pharmacodynamics of drugs delivered to the lungs, G. Hochhaus; methods of generation, administration and characterization of aerosols - theoretical principles and devices used to generate aerosols for research, Keng H. Leong; the design and development of inhalation drug delivery systems, Paul J. Atkins, Nicholas P. Barker and Donald Mathisen; aerosol-filling equipment for the preparation of pressurized pack pharmaceutical formulations, Christophe Sirand, Jean-Pierre Varlet and Anthony J. Hickey; methods of aerosol particle size characterization, Anthony J. Hickey; summary of common approaches to pharmaceutical aerosol administration, Anthony J. Hickey. Clinical aspects of aerosol administration and future perspectives: therapeutic aerosols - an overview from a clinical perspective, F. Charles Hiller; aerosolized pentamidine for treatment and prophylaxis of pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome, Bruce montgomery; the application of aerosolized antimicrobial therapies in lung infections, Dennis Williams; gene delivery to the lung, Justin Hanesl; recent advances related to the systemic delivery of therapeutic molecules by inhalation, David Edwards; modulated drug therapy with inhalation aerosols - revisited, Ralph W. Niven; pulmonary delivery technology - advances of the last decade and potential for the new millennium, Andy Clark.
Anthony J. Hickey University of North Carolina at Chapel Hill, USA.