Experimental Therapeutics
Informa Healthcare, March 2003, Pages: 248
As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine.
Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.
DRUG DISCOVERY AND DEVELOPMENT
The Clinical Pharmacologist's View: Drug Discovery and Early Developments, Sir Colin Dollery
The Toxicologist's View: Non-Clinical Safety Assessment, Anthony Lynch and John Connelly
The Regulator's View: Regulatory Requirements for Marketing Authorizations for New Medicinal Products in the European Union, Rashmi R. Shah, Sarah K. Branch, and Christopher Steele
CLINICAL PHARMACOLOGY. PRINCIPLES OF PHARMACOKINETICS
The Use of Pharmacogenetics to Maximize Therapeutic Benefit, Andrew G. Renwick
Drug Chirality: Pharmacology in Three Dimensions, Christian Meisel, Matthias Schwab, and Andrew J. Hutt
Surrogate Endpoints, James J. Oliver and David J. Webb
Positron Emission Tomography (PET) as a Tool in Pharmacology: Examples from Neuroscience, Eugenii A. Rabiner and Paul M. Grasby
NOVEL THERAPIES
Targeting Nuclear Receptors: PPARs as Targets for Drug Design, Colin N.A. Palmer and Martin R. Wilkins
The Use of Antisense Oligonucleotides as Therapeutic Agents, Punit Ramrakha
Gene Therapy: Theoretical and Practical Aspects, Rebecca Kristeleit and Martin R. Wilkins
Index
Martin R. Wilkins, MD, FRCP, is Professor of Clinical Pharmacology, Division of Medicine, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, UK
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