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Lipid Nanocarriers in Cancer Diagnosis and Therapy
Smithers Information Ltd, Aug 2011, Pages: 557
This book introduces fundamental principles of lipid nanocarriers science relevant to cancer therapy. The first in this field, it fills a need for an accurate, coherent and authoritative introduction to lipid nanocarriers focusing in cancer therapy; both because of the growing popularity of these modern drug delivery systems and also because of the emergent need of dealing with cancer treatment.
Active drug delivery and targeting using nanobiotechnologies has become one of the most successful strategies to approach chemotherapy. This book deals with lipid nanocarriers for targeted delivery to tumours of various organs and combination of these with other methods of treatment of cancer such as radiotherapy, diagnostic and imaging analysis. Lipid nanocarriers are also used for gene therapy for cancer.
Also addressed is how diagnostic strategies with lipid nanocarriers can be combined with therapeutics, which will be important for the personalized management of cancer.
Cancer chemotherapeutic drugs are also being used as immunosuppressive agents in the chronic treatment of non-neoplastic diseases. The scientific research in this field has been focused on the development of strategies to target and deliver several cancer chemotherapeutic drugs to decrease citotoxicity. These include both carrier- and receptor-mediated nanocarriers. Being biodegradable and biocompatible systems, lipid nanocarriers have been extensively explored to increase its therapeutic index, reducing adverse side effects to ultimately extend life-span of patients.
Furthermore, a familiarity with lipid materials science will enable scientists to conduct rational performulation studies, to understand and optimize formulations, drug delivery systems and their manufacturing processes as well as associated process analytical technologies and quality by design.
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