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Filamin: a scaffolding protein. Edition No. 1

  • ID: 1894004
  • May 2010
  • 216 Pages
  • VDM Publishing House
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Filamin is an actin-binding protein known to be essential for wild type slug phototaxis in D. discoideum. The protein contains an actin-binding domain (ABD) followed by a rod domain containing 6 closely related repeat segments. Here I show that repeats 2-6 in the rod domain and the ABD are essential for wild type phototaxis, suggesting that when these segments are missing proteins which bind to these segments are excluded from the photosensory pathway and phototaxis is impaired. Repeat 1 was shown not to be essential if filamin?1 was overexpressed to levels 10X higher than wild type filamin. This indicates that repeat 1 is not involved in directly binding proteins but is still required for the formation of fully functional complexes. Coimmunoprecipitation experiments identified 5 filamin-interacting proteins-RasD, Erkb, AMPK, PKB

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Sarah, Annesley.
I began my studies at La Trobe University, Australia completing an undergraduate degree in Biological Science and obtaining first class honours in Microbial Genetics. I developed an interest in signalling pathways and the model organism Dictyostelium and completed my PhD which encompassed both these interests.

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