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Viewing report
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Characterisation of Jack Jumper Ant Venom. Edition No. 1
VDM Publishing House, Aug 2008, Pages: 192
Ant sting allergy in Australia is predominantly due
to the Myrmecia pilosula species complex (Jack
Jumper Ant, JJA) and venom immunotherapy has been
shown to be effective in preventing anaphylaxis to
the sting of this ant. This work describes the
development of a number of analytical
techniques to separate and characterise JJA venom
components. These techniques were then used to
determine the allergenicity of previously described
venom peptides in their native forms, identify
additional allergens and to update nomenclature used
to describe the allergens. They were subsequently
applied to the standardisation of venom prior to new
batches being used for the diagnosis and treatment
of JJA sting allergy. Myr p 2 was found to be the
only major allergen in JJA venom, whilst Myr p 1 and
Myr p 3 were minor allergens. There were an
additional five IgE-binding proteins that require
further characterisation before they can be named as
allergens. A standardisation procedure was validated
that is able to control the quality of venom so that
it complies with the requirements described in the
European Pharmacopoeia.
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