|
|
 |
|
Viewing report
|
|
|
|
Deformable Microparticles with Multiple Functions
for Drug Delivery. Edition No. 1
VDM Publishing House, Aug 2008, Pages: 132
Since the HIV epidemic of the 1990s, researchers
have attempted to develop a red blood cell analog.
Even though some of these substitutes are now in
Phase III of clinical trials, their use is limited
by side effects and short half-life in the human
body. As a result, there is still a need for an
effective erythrocyte analog with minimum
immunogenic and side effects, so that it can be used
for multiple applications. Finding new approaches
to develop more efficient blood substitutes will not
only bring valuable advances in the clinical
approach, but also in the area of in vitro testing
of medical devices.
This work examined the feasibility of creating a
deformable multi-functional, biodegradable,
biocompatible particle for applications in drug
delivery and device testing. As a preliminary
evaluation, different types of microcapsules were
synthesized using natural and synthetic polymers,
various cross-linking agents, and diverse
manufacturing techniques. After fully
characterizing of each system, the most promising
red blood cell analog in terms of deformability,
stability and toxicity was determined.
|
|
|
|
