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BIOMIMETIC SENSOR FOR INVIVO APPLICATIONS. Edition No. 1
VDM Publishing House, Sep 2008, Pages: 92
The development of sensitive specific devices (e.g.,
molecular sensors) for the detection, diagnosis and
monitoring of diseases, drug discovery,
environmental detection of pollutants and/or
biological agents has been an active area of
research. A molecular sensor is a biomolecule or
biomimetic molecule that performs two distinct
functions in detecting target molecules. The sensor
molecule recognizes a target molecule and
specifically binds to it. This specific binding
generates a signal in response to the event of
target binding that can be then detected. The long
term vision of this thesis research work is to
develop a specific recognition ligand for detecting
proteins in living cell.
The purpose of this research is to develop
method for designing and engineering nucleic acid
molecules, aptamer molecules that are capable of
functioning like molecular beacons, except that they
respond to non-nucleic acid molecules. The aptamer
beacon concept can be generalized to the detection
of different types of molecules/proteins such as
small molecules (e.g. glucose) or large molecules.
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