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An inverse cardiac electrophysiological approach.. Edition No. 1

VDM Publishing House, May 2009, Pages: 172


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Noninvasive estimation of myocardial electrical
activity traditionally used potential measurements on
the human body surface, such as body surface
potentials(BSPs, pl.) or electrocardiograms (ECGs,
pl.). But because of non-unique mapping between
myocardial electrophysiological activity and sparse
body potential measurements, the performances of
previous efforts have not been well accepted. In this
book, a different aspect to understand myocardial
electrophysiological activity is established for the
first time: since the mechanical activity of the
myocardium is mainly driven by myocardial
electrophysiological activity, patient-specific
myocardial kinematic measures should, indirectly,
reflect the propagation of cardiac transmembrane
potential(TMP). Coupling the physiological modeling
of myocardial electro-mechanical behavior on the
meshfree particle representation, my proposed inverse
approach recovers myocardial electrophysiological
activity from medical image sequences through
regularization or Kalman filter with favor results.




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