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Defining the Role of Particle Surface Area in Pulmonary Toxicity. Edition No. 1

VDM Publishing House, December 2008, Pages: 264

The production and use of nanoparticles is growing
rapidly due to the unique physical and chemical
properties associated with their nano-size and large
surface area. As the field of nanotechnology vastly
expands, many questions involving the effects of
nanomaterials on the environment as well as human
health have been raised. The objective of this book
is to address the growing concern of nanoparticle
pulmonary toxicity. Not until the recent increase in
utilization of nanoparticles in industry, have the
dangers of pulmonary exposure to nanoparticles become
a major concern. Analyzes of the dangers of
nanoparticle exposures are presently at the forefront
of environmental and occupational risk assessment
studies. The primary objective of this study is to
assess the pulmonary toxicity of ultrafine and fine
carbon black and titanium dioxide in vivo on both a
mass dose of particle basis as well as on a dose
normalized to particle surface area administered.
The results of these studies will be utilized to
answer the question of whether mass of particles
administered or surface area of particles
administered is a more accurate dose metric to be
employed in pulmonary toxicity studies.

Tina, Sager.
Tina M. Sager, Ph.D.: Studied Cellular and Integrative Physiology
with an emphasis in Toxicology at West Virginia University School
of Medicine, Morgantown, WV. Currently a Research Fellow at
Harvard University, Harvard School of Public Health, Department
of Environmental Health, Boston, Mass.