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NITRIC OXIDE SYNTHASE IN PANCREATIC ISLETS. Edition No. 1 - Product Image

NITRIC OXIDE SYNTHASE IN PANCREATIC ISLETS. Edition No. 1

  • Published: May 2009
  • 184 Pages
  • VDM Publishing House

The influences of trauma and TPN on pancreatic islet
hormone secretion in relation to islet expression of
iNOS synthase was investigated.

Acute pancreatitis resulted in an impaired glucose-
stimulated insulin secretion (GSIS), which was found
to be parallelled by a marked expression of iNOS and
an exaggerated NO production in the pancreatic
islets.
A characteristic feature of long term TPN-treatment
is hyperlipidemia and euglycaemia. TPN treatment
impairs GSIS at least in part through a reduced
cyclic AMP production in parallell with an exclusive
expression of iNOS, which was reflected in an
increased NO production accompanied by enhanced
cyclic GMP formation by islets.
Agents stimulating cyclic AMP/PKA i.e. PACAP27 and
PACAP38 were capable of not only inhibiting neuronal
NOS (ncNOS) but also counteracting the expression of
iNOS induced by intralipid infusion. The suppressed
NO production in the presence of PACAPs was
reflected in a suppressed cyclic GMP and a marked
increase in cyclic AMP production by pancreatic
islets.
Finally, effects of ghrelin on islet hormone
secretion and NOS isoenzymes activities were also
studied.

Saleem Saaed, Qader.
2007: MD (Physician Authorization), Swedish Social Welfare
Board, Sweden
2004: PhD in Surgery, Lund University, Lund, Sweden
2004: MPH, Lund University, Malmö, Sweden
1997: Specialist Surgeon, Rizgary Teaching
Hospital, Arbil, Iraq
1996: MSc in Surgery, Salahaddin University, Arbil, Iraq
1987: MBChB, Baghdad University, Baghdad, Iraq

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