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Viewing report
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Exercise and the Ischemic Brain. Edition No. 1
VDM Publishing House, May 2009, Pages: 120
Stroke is one of the leading causes of disability
and the hemiplegic upper extremity is particularly
resistant to rehabilitation intervention. Endurance
exercise, outside of its beneficial effects on the
cardiovascular and musculoskeletal systems,
influences brain remodelling, learning, and memory.
In our experiments, we determined the effects of
exercise on critical mediators of neuroplasticity
(brain-derived neurotrophic factor (BDNF), insulin-
like growth factor (IGF-I), synapsin-I,
phosphorylated cyclic AMP response element binding
protein (pCREB) and serum corticosterone) in a rat
model of middle cerebral artery stroke. It was clear
the intensity and duration of exercise had
differential effects on proteins that affect
neuroplasticity after stroke. Furthermore, animals
receiving running exercise preceding a skilled
reaching task recovered better than animals that did
not. Endurance exercise appears to have an enhancing
effect on learning of a subsequent reaching skill
mediated in part by structural changes within the
brain. This phenomenon may be beneficial when
arranging therapeutic activities during stroke
rehabilitation.
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