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Function of Lung. Edition No. 1

VDM Publishing House, April 2010, Pages: 104

The alveoli of mammalian lungs are covered in a thin lipid film referred to as pulmonary surfactant. The primary purpose of pulmonary surfactant is to reduce the surface tension of the air/liquid interface allowing breathing with minimal effort required. We investigated the effect of addition of cholesterol and amyloid-? peptide on structure and function of Bovine Lung Extract Surfactant (BLES) and model lipid films. In our first experiment, we have demonstrated the effect of amyloid-? and cholesterol on lipid films of DPPC, DPPC-DOPG and BLES. We saw that cholesterol inhibits multilayer formation in all monolayers. Amyloid-? increases multilayer formation in DPPC and DPPC-DOPG, but reduced multilayer formation in BLES. When cholesterol and amyloid-? is added to BLES, 1% amyloid-? is inconsequential, whereas 10% amyloid-? allows BLES to regain some of its surfactant function.

Victoria, Blades.
Victoria Blades a Master of Science in Biology Flinders University, Australia.