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Viewing report
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Central Neural Control of the Kidney. Edition No. 1
VDM Publishing House, Oct 2008, Pages: 296
This study was undertaken to locate and characterise
the neurons in
the central nervous system that project to the
kidney. A retrograde
transsynaptic viral tracer was injected into the
kidney of rats and
traced through the neuraxis to locate these neurons.
The results
show that a polysynaptic neural pathway extends from
multiple
forebrain sites including several novel autonomic
sites, and projects
successively through the brainstem, spinal cord and
peripheral ganglia
en route to the kidney. This pathway is activated in
response to
stimuli associated with the regulation of body fluid
balance. Both
classical amino acid transmitters, and neuropeptides
likely mediate
these effects. This work lays the foundation for
potential therapeutics
in the treatment conditions of renal failure in which
the central
circuitry projecting to the renal nerves is compromised.
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