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Viewing report
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Customized Contact Lens Treatments for in-the-Eye
Medication. Edition No. 1
VDM Publishing House, May 2009, Pages: 180
Hydrophilic polymer (polymacon, alphafilcon-A) and
silicone-based (balafilcon-A) hydrogel contact
lenses, before and after surface modification by
radio-frequency glow-discharge treatment (RFGDT),
were used to monitor methylene blue/silver nitrate
drug-surrogate uptake and elution. Infrared
spectroscopy revealed modified absorption peaks,
accordingly. Energy-dispersive x-ray (EDX) analysis
and inductively coupled argon plasma atomic emission
spectroscopy (ICP) confirmed silver lens depot
concentrations and were employed to measured eluate
concentrations, while visible spectrophotometry and
ICP spectrometry monitored methylene blue and silver
elution rates in static versus simulated eye-blinking
conditions. The conclusions reached are that (1)
initial drug uptake of surface modified lenses
increased in this order: polymacon alphafilcon-A
balafilcon-A lenses; (2) drug release rates of the
polymacon, and alphafilcon-A remained unaffected by
the RFGDT; (3) increased release rates occurred from
the RFGDT-surface-modified balafilcon-A lenses; and
(4) dynamic forces increased the release rates for
all contact lenses.
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