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Synthesis & biological investigation of fluorinated amino acid analogs. Edition No. 1

VDM Publishing House, February 2012, Pages: 100

Integrins are cell surface receptors that take part in cell – cell adhesion and cell – extracellular matrix (ECM) adhesion events as well as in cell migration and cell signaling. a5ß1 integrins are expressed on a wide range among brain tumor cells. In this study, an intermediate spiroisoxazolinopyrrole of the most specific a5ß1 integrin antagonist SJ749 was synthesized. Fischer esterification reaction, Swern oxidation, and Wittig olefination were performed. Next, fluorinated diaminopropionate molecules were synthesized for coupling to SJ749 instead of the (2,4,6-trimethylphenyl) diaminopropionate. Finally, the biological evaluation of the molecules synthesized was performed. These assays included cytotoxicity and cell proliferation.

Olexandra, Dubovyk.
MA in Gender Studies (Central European University, Hungary), MA and BA in Technical Translation (National Metallurgical Academy of Ukraine), BA in Finance (Dniepropetrovs'k National University, Ukraine). Currently works as main specialist on cooperation with social services at local government body in one of the regional centers in Ukraine.