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Physico-Chemical Properties of Drug-Additive Systems. Edition No. 1 - Product Image

Physico-Chemical Properties of Drug-Additive Systems. Edition No. 1

  • ID: 1921011
  • February 2012
  • 168 Pages
  • VDM Publishing House

A most common challenge faced by pharmaceutical scientists as well as industry is to design and develop drugs with good aqueous solubility while simultaneously retaining potency and selectivity. This problem can be overpowered by the use of mixed micelles of drug–surfactant or surfactant–surfactant. The results would be helpful towards the development of drug formulations which will expectedly help in removing their disadvantages towards accumulation within bio-membranes. The amphiphilic drugs, because of their surfactant-like nature, exhibit concentration, temperature and pH-dependent phase separation (clouding), therefore, it is important to have knowledge of clouding behavior of the drugs in designing more effective drug-carrier combinations. With this idea in mind, effects of various additives, viz., electrolytes, non-electrolytes, alcohols, surfactants, sugars, and amino acids have been examined on clouding behavior of some amphiphilic drugs.

Baharudin, Abdullah.
Baharudin Abdullah is an Associate Professor and Consultant at the School of Medical Sciences, Universiti Sains Malaysia. Muhammad Yusri Musa is a consultant at the Advanced Medical and Dental Institute, USM. John Tharakant is a neurologist at the Dept of Neuroscience, USM.
Muhammad, Yusri Musa.
Baharudin Abdullah is an Associate Professor and Consultant at the School of Medical Sciences, Universiti Sains Malaysia. Muhammad Yusri Musa is a consultant at the Advanced Medical and Dental Institute, USM. John Tharakant is a neurologist at the Dept of Neuroscience, USM.
John, Tharakant.
Baharudin Abdullah is an Associate Professor and Consultant at the School of Medical Sciences, Universiti Sains Malaysia. Muhammad Yusri Musa is a consultant at the Advanced Medical and Dental Institute, USM. John Tharakant is a neurologist at the Dept of Neuroscience, USM.

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