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Life at the Nanoscale: Atomic Force Microscopy of Live Cells
Pan Stanford Publishing Pte. Ltd, July 2011, Pages: 444
The nanoscale analysis of living cells using atomic force microscopy (AFM)-based techniques is an exciting, rapidly evolving research field. During the past years, there has been tremendous progress in using AFM to observe cell surfaces at high resolution, to study cellular mechanics, to localize cell surface receptors, and to measure the forces involved in cellular interactions. This timely book provides a comprehensive overview of the use of AFM and related scanning probe microscopies for cell surface analysis, from the basics to the applications. The book will appeal to anyone involved in cell biology, microbiology, biophysics, biochemistry, or nanobiosciences. It covers all cell types, from viruses and protoplasts to bacteria and animal cells, and discusses a range of advanced AFM modalities, including high-resolution imaging, nanoindentation measurements, recognition imaging, as well as single-molecule and single-cell force spectroscopy. The different chapters are authored by cutting-edge experts, each representing his or her specialized areas. Each chapter covers methodologies for sample preparation and analysis, and highlights recent examples to illustrate the power of AFM techniques in life sciences and nanomedicine.
At the crossroads of nanoscience and life sciences, the nanoscale analysis of living cells using atomic force microscopy (AFM)-based techniques is an exciting, rapidly evolving research field. During the past years, there has been tremendous progress in the use of AFM to observe cells and membranes at high resolution. Remarkable advances have also been made in the application of force spectroscopy techniques to study cellular mechanics, to localize single receptors on live cells, and to measure cellular interactions. These AFM-based measurements contribute to improve our understanding of the structure–function relationships of cell walls and membranes and have a strong potential in biomedicine, e.g., for elucidating the mechanisms of cell–drug and pathogen–host interactions.
This timely book provides a comprehensive overview of the use of AFM and related scanning probe microscopies for cell surface analysis, going from the basics to the applications side. The book will appeal to anyone involved in cell biology, microbiology, biophysics, biochemistry, or nanosciences. It is the first of its kind to cover all cell types, going from viruses and protoplasts to bacteria and animal cells and to discuss a range of advanced AFM modalities, including high-resolution imaging, nanoindentation measurements, recognition imaging, and single-molecule and single-cell force spectroscopy. The chapters are authored by cutting-edge experts, each representing their specialized areas. The book covers methodologies for preparing and analyzing cells and membranes of all kinds and highlights recent examples to illustrate the power of AFM techniques in life sciences and nanomedicine.
Key Features:
- Published in full-color with numerous illustrations.
- Comprehensive overview of the use of atomic force microscopy and related scanning probe techniques for analyzing cells and membranes, going from the basics to the applications side.
- Extensive bibliography for further reading.
Readership
Students and researchers in the fields of nanotechnology, biophysics, cell biology, microbiology, and biomedicine.
About the Author
Yves Dufrêne received his engineering degree in chemistry and bioindustries (in 1991) and a PhD degree in biophysical chemistry (in 1996) at the Université catholique de Louvain (UCL, Belgium). After a postdoc at the Naval Research Laboratory (Washington DC, USA), he became research associate (2000) of the Belgian National Fund for Scientific Research and lecturer in physical chemistry and nanobiotechnology at UCL. He is currently the head of the Laboratory of Chemistry of Interfaces.
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