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Viral Nanoparticles: Tools for Materials Science and Biomedicine
Pan Stanford Publishing Pte. Ltd, June 2011, Pages: 284
The utilization of viral nanoparticles (VNPs) in nanosciences and nanotechnology has become a popular field of research. From a materials science point of view, VNPs are attractive building blocks for several reasons: The particles are on the nanometer size scale, they are monodisperse with a high degree of symmetry and polyvalency, they can be produced with ease on large scale, and they are exceptionally stable and robust, biocompatible, and bioavailable. VNPs are “programmable” units that can be modified by either genetic modification or chemical bioconjugation methods.
This book gives an overview of the applications of VNPs in the areas ranging from materials science to biomedicine and provides a summary of the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. Turning toward potential applications, the book outlines the strategies for the construction of 1-, 2-, and 3-D arrays. It also highlights the manifold achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices. The book also describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Key Features
- Comprehensive overview of the manifold applications of VNPs in nanotechnology; covers the research from scientists from all over the world
- Explains technical terminology to facilitate a common interdisciplinary language
- Written for young and established researchers working on or interested in viral nanotechnology
Readership
Undergraduate and graduate students, postdoctoral fellows, and established researchers in viral nanotechnology, virology, nanotechnology, materials science, and biomedicine.
About the Authors
Dr. Nicole F. Steinmetz is assistant professor of biomedical engineering at Case Western Reserve University, Cleveland, Ohio. Dr. Steinmetz’s major area of professional interest lies in the application of complex viral nanoparticle (VNP) formulations for biomedicine and materials science. As a postdoctoral fellow at The Scripps Research Institute, La Jolla, California, her efforts have focused on the development of VNP formulations for cancer detection and treatment (2007–2010). During her dissertation work in the field of nanotechnology at the John Innes Centre, Norwich, UK, she created multiple 3D VNP multilayered thin-film arrays for potential applications in sensors or nanoelectronics (2004–2007). Dr. Steinmetz is a 2009 recipient of the NIH/NIBIB Pathway to Independence Grant (K99/R00), a previous American Heart Association Postdoctoral Fellow, former Marie Curie EST Fellow, winner of the Bryan Harrison Prize (2006), and 2007 Biosciences Federation Science Communication Award winner. Her early training was at RWTH Aachen University, Germany, where she received her diploma (equivalent to masters) with honors in molecular biology in 2004.
Dr. Marianne Manchester specializes in novel virus-based nanotechnologies for tumor targeting and vaccine development. She has developed tissue-directed nanoparticles that show specificity for tumors in vivo and was the first to demonstrate the utility of viral nanoparticles as a tool for intravital vascular imaging. She has been instrumental in developing virus-based structural scaffolds for antigen presentation that demonstrate the positive effects of whole antigen display and antigen multivalency on protective immunity. Since 2002, she has led NIH-sponsored programs in tumor nanotechnology and multivalent nanotechnologies for vaccine development. She has also developed novel mass spectrometry-based approaches for identifying new therapeutic targets for human disease.
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