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Vaccines in Clinical Trials: Infectious Diseases

Expert Reviews Ltd, May 2011, Pages: 154


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The last 50 years has seen a fantastic acceleration in the development, testing and implementation of life-saving vaccines that are now given routinely in clinical practice and in childhood in particular. Development of each of these vaccines has involved pathogen discovery, antigen identification, laboratory development and assessment of safety, immunogenicity and efficacy. The articles presented in this Special Focus Issue of the peer-reviewed journal Expert Review of Vaccines lay out the current status of a broad range of bacterial and viral infectious diseases, unified by the fact that each represents a major disease burden with enormous clinical need. Each of the 8 review articles outlines innovative vaccine developments that have proceeded successfully to the point of clinical study in man, but in which efficacy is not yet fully established. These exciting articles outline both the disease and the work that will continue to dominate the scientific literature in the coming years.


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