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Immune Cells & Inflammation
Future Medicine Ltd, Oct 2011, Pages: 148
This Special Focus Issue of the peer-reviewed journal Immunotherapy, discusses the immune cross-talk driven by natural killer cells, the split personality of NKT cells and macrophages in malignancy, autoimmune disorders and infectious disease, the two-sided roles of dendritic cells in the pathogenesis and treatment of human disease, the pleiotropic functions of naive, effector and memory CD8 T cells and tumor-infiltrating lymphocytes, and how lymphocyte function may be influenced by the stromal cell network affecting the inflammatory process. Targeting the immune cells located in the inflamed tumor microenvironment by altering their function to induce an acute inflammatory switch may represent a logical approach to therapy.
This collection will promote a global and dynamic approach to immunotherapy encouraging clinical and basic investigator to abandon the stiffness of the current taxonomic interpretation of immunity in favor of a malleable functional interpretation.
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