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Protein Chaperones and Protection from Neurodegenerative Diseases
John Wiley and Sons Ltd, Aug 2011, Pages: 448
This book describe the various roles that chaperones play in protecting against neurodegenerative diseases such as ALS, Parkinsons disease, polyglutamine diseases, and prion diseases. It provides an in-depth examination of how different protein chaperones ameliorate the toxicity of proteins that are known to be involved in various neurodegenerative diseases.
It addresses from both research and clinical perspectives the chaperone and anti-chaperone properties of various proteins such as alpha-synuclein, Hsp70, Hsp104, Hsc90, Chaperonin TRiC, ER stress and chaperone production, as well as emerging areas sucha s torsinA and its possible role in neurodegeneration.
The final chapter discusses the potential to harness the power of protein chaperones, and future directions of research, discovery, and therapeutics.
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