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Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
John Wiley and Sons Ltd, Aug 2011, Pages: 568
This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery.
The book describes physiochemical, biological, and dietary factors that effect oral bioavailability. It covers drug interactions and formulation factors to improve bioavailability. and provides an easy-to-understand section for scientists to understand ADME. The book is a practica guide for the use of several state-of-the-art technologies and methodologies like computational methods and approaches to predict bioavailability, descriptions of the Caco 2-cell model, MDCK, intestinal perfusion, and in vivo pharmacokinetics.
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