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Handbook of Dynein
Pan Stanford Publishing Pte. Ltd, Nov 2011, Pages: 350
This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give the reader a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students.
Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.
Readership
Graduate students studying cell, molecular or structural biology, biochemistry, and biophysics; researchers in molecular and structural biology and biophysics.
Key Features
- Comprehensive coverage of cytoplasmic dynein as well as dyneins in cilia and flagella
- Unique in its coverage of biophysical data, including high-resolution structural information
- Unprecedented coverage of recent studies using single-particle methods
- Information from recombinantly expressed proteins as well as native complexes.
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