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Brain Diseases and Metalloproteins
Pan Stanford Publishing Pte. Ltd, Feb 2012, Pages: 350
This book will cover neurodegenerative diseases (brain diseases) where the proteins that cause them are now known to be metal binding proteins. This is one of the leading fields of new research into these diseases and as time goes by a lot of new and interesting insights have been gained that may one day lead to treatment of these diseases. The book will contain research from leading experts in the field who work on aspects ranging from pure chemistry of metal binding to clinical aspects of the diseases and the use of chelators in possible treatment.
The book will consist of a series of reviews by different authors (10-15), edited by David Brown, University of Bath, UK. The authors will all be experts in the field who have made a major contribution in recent years. The chapters will describe the latest research on neurodegenerative disease and metal binding proteins. There will be strong emphasis on biochemistry and cell biology with some chapters by chemists. The diseases covered with include Parkinson's disease, Alzheimer's disease, prion disease and ALS. The different chapters will examine such issues as mechanisms of metal binding, metal induced structural changes in proteins, alterations in cellular metal metabolism in disease, attempts at a therapeutic approach based on protein metal binding.
The most up to date research will be featured and presented in context with background of the disease making the book accessible to postgraduate students and specialist alike. It will appeal to basic researchers in the lab to specialist clinicians who want to keep up with the latest research discussed in an authoritative manner.
Readership:
Experts working the in fields of metallochemistry or neurodegeneration (ie biologists and chemists). University students on specialist courses relating to these fields.
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