Advanced Wound Repair Therapies

Woodhead Publishing Ltd, June 2011, Pages: 672

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. "Advanced Wound Repair Therapies" provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.

Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.

With its distinguished editor and international team of contributors, "Advanced Wound Repair Therapies" is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.

Key features:

- provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds
- chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing
- covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

PART 1: INTRODUCTION TO CHRONIC WOUNDS

Dysfunctional wound healing in chronic wounds
P Stephens, Cardiff University, UK
- Normal skin wound healing
- Ageing skin and the onset of chronic, dysfunctional wound healing
- Dysfunctional healing of chronic skin wounds
- Conclusions
- Acknowledgements
- References

The role of micro-organisms and biofilms in dysfunctional wound healing
J G Thomas, H Motlagh, S B Povey and S L Percival, West Virginia University, USA
- Introduction
- Microbiology and biofilms: not mutually exclusive
- Biofilms and the interactive cooperative community
- Biofilms in chronic wounds
- Biofilms as therapeutic or restorative microbiology/modelling
- Conclusion
- References

Scarring and scarless wound healing
B J Larson, A Nauta, K Kawai, M T Longaker and H P Lorenz, Stanford University School of Medicine, USA
- Introduction
- Wound healing process
- Fibroproliferative scarring
- Scarless fetal wound healing
- Adult versus fetal wound healing
- Treatment options for scars
- Future trends
- Conclusions
- References

The discovery and development of new therapeutic treatments for the improvement of scarring
N L Occleston, A D Metcalfe, A Boanas, N Burgoyne, K Nield, S O’Kane and M W J Ferguson, Renovo Group Plc, UK
- Introduction
- Scar-free and scar-forming healing
- In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments
- Translation from pre-clinical studies to clinical efficacy
- Understanding the mechanisms of action of prophylactic scar improvement therapies
- Conclusions
- References

Monitoring chronic wounds and determining treatment
P Plassmann, University of Glamorgan, UK
- Introduction
- Wound size measurements
- Wound colour measurements
- Background material
- References

PART 2: BIOMATERIAL THERAPIES FOR CHRONIC WOUNDS

Functional requirements of wound repair biomaterials
R M Day, University College London, UK
- Introduction
- Wound pain and dressing materials
- Exudate management
- Prevention and control of infection
- Odour management
- Future trends
- Sources of further information and advice
- References

Tissue-biomaterial interaction
S Downes and A A Mishra, University of Manchester, UK
- Introduction: definitions
- Overview of tissue-biomaterial interactions
- Interactions at the biomaterial surface
- Tissue response to biomaterial
- Conclusion
- References

Polymeric materials for chronic wound and burn dressings
A Agarwal, J F McNulty, M J Schurr, C J Murphy and N L Abbott, University of Wisconsin, USA
- Introduction
- Advanced moisture-retentive wound dressings
- Polymeric materials in moist wound healing dressings
- Infection control by polymeric wound dressings
- Conclusion
- Future trends
- Acknowledgements
- References

Dry wound healing concept using spray-on dressing for chronic wounds
S Jolly and S Jolly, Clinogen Ltd, UK
- Principles of dry wound healing using a protein based spray-on dressing
- The key properties of an ideal wound dressing
- Using protein-based spray-on dressings in practice
- Case studies
- Conclusions
- References

Assessing the effectiveness of antimicrobial wound dressings in vitro
J Vaughan, R Benson and K Vaughan, Smith and Nephew Research Centre, UK
- Introduction
- Log reduction testing
- Zone of inhibition (ZOI)
- Bacterial barrier testing
- Other considerations
- Sources of further information and advice
- References

Adhesives and interfacial phenomena in wound healing
B J Tighe and A Mann, Aston University, UK
- Principles of adhesion, adhesivity and interfacial behaviour
- Bioadhesion: principles of adhesion applied to wound healing
- Adhesives in wound healing: materials overview
- Surgical adhesives and tissue sealants: structure and properties
- Conclusions
- References

Wound healing studies and interfacial phenomena: use and relevance of the corneal model
A Mann and B J Tighe, Aston University, UK
- Wound dressing biomaterials: interfacial aspects of compatibility and wound response
- The corneal model in wound healing and biomaterial studies
- Interfacial phenomena in ocular surface contact lens studies
- Wound fluid and the tear film collection
- Biomaterials in mucosal wound healing
- Conclusions
- References

Sulphonated biomaterials as glycosaminoglycan mimics in wound healing
B J Tighe and A Mann, Aston University, UK
- Introduction
- Polymers and biomimesis
- Biomimetic models
- Sulphonated biomaterials in the context of biomimetic principles
- Sulphonated biomaterials and the chronic wound: possible modes of biomimetic behaviour
- Conclusions
- References

PART 3: MOLECULAR THERAPIES FOR CHRONIC WOUND

Drug delivery dressings
K H Matthews, Robert Gordon University, UK
- Introduction
- The role of drug delivery dressings in wound management
- Topically delivered therapeutic compounds
- Hydrocolloids
- Hydrogels
- Collagen
- Alginates
- Honey
- Future trends
- References

Molecular and gene therapies for wound repair
E Kiwanuka, F Hackl, D Nowinski and E Eriksson, Harvard Medical School, USA
- Introduction
- Methods of gene delivery
- Gene therapy for wound healing
- Ethical issues
- Future trends
- References

Antimicrobial dressings
M IP, Chinese University of Hong Kong, Hong Kong
- Introduction
- Types of currently available dressings/formulations
- Types of ‘antimicrobials’
- Future trends
- References

Avotermin: emerging evidence of efficacy for the improvement of scarring
J A Bush, K So, T Mason, N L Occleston, S O’Kane and M W J Ferguson, Renovo Group Plc, UK
- There is a medical need for therapies that reduce scarring following surgery
- Current treatments for scar management are unsatisfactory
- New biological approaches are in development for the prophylactic improvement of scarring
- Conclusions and future trends
- References

PART 4: BIOLOGICALLY-DERIVED AND CELL-BASED THERAPIES FOR CHRONIC WOUNDS

Engineered tissues for wound repair
N J Turner and S F Badylak, University of Pittsburgh, USA
- Introduction
- The wound microenvironment in wound repair
- Traditional approaches to wound repair
- Development of cellular therapies
- Development of acellular therapies
- Conclusion
- Acknowledgements
- References

Commercialisation of engineered tissue products
N L Parenteau, Parenteau BioConsultants LLC, USA
- Introduction
- Engineered templates and scaffolds
- Processed tissues
- Cell-based products
- Lessons from the first generation
- The second generation of advanced therapies
- Delivering value in advanced therapies
- Advanced therapies in the marketplace
- Conclusion
- References

Biologically derived scaffolds
K Numata, RIKEN Institute, Japan and D Kaplan, Tufts University, USA
- Introduction
- Polyhydroxyalkanoate (PHA)-derived scaffolds
- Silk-derived scaffolds
- Collagen-derived scaffolds
- Elastin-derived scaffolds
- Resilin-derived scaffolds
- Keratin-derived scaffolds
- Polysaccharide-derived scaffolds
- Conclusions and future trends
- References

Stem cell therapies for wound repair
G G Gauglitz and M G Jeschke, Shriners Hospitals for Children, USA
- Introduction
- Frequently utilized sources of adult stem cells
- Clinical applications of stem cells to wound healing
- Conclusions
- Acknowledgement
- References
- Appendix: List of abbreviations

PART 5: PHYSICAL STIMULATION THERAPIES FOR CHRONIC WOUNDS

Electrical stimulation for wound healing
K Balakatounis, Oxford Brookes University, UK
- Introduction
- Current of injury
- Physiological effects of electrical stimulation
- Antibacterial effects of electrical stimulation
- The effect of high voltage pulsed current (HVPC) on wound healing
- The effect of low intensity direct currents (LIC) on wound healing
- Other types of electrical stimulation applied to wounds
- Discussion
- Conclusion
- References

Negative pressure wound therapy
M S Miller, The Wound Healing Centers of Indiana, USA
- Introduction
- History of negative pressure wound therapy
- The science of negative pressure
- The pathophysiologic mechanisms of action of negative pressure
- The search for the perfect negative pressure technology
- Conclusions
- Acknowledgement
- References

Debridement methods of non-viable tissue in wounds
D Leaper, Imperial College and Cardiff University, UK, S Meaume, Hôpital Charles Foix, France, J Apelqvist, University Hospital of Skåne, Sweden, L Teot, Hopital LaPeyronie, France, and F Gottrup, Copenhagen Wound Healing Center, Denmark
- Introduction
- Complications of non viable tissue in wounds and the need for debridement
- Timing and types of debridement
- Scoring the effectiveness of debridement
- Debridement in the diabetic foot
- Conclusions
- Sources of further information and advice
- References

David Farrar is Science Manager for Biomaterials at the Smith and Nephew Research Centre, York, UK

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