Injectable Biomaterials: Science and Applications
Woodhead Publishing Ltd, January 2011, Pages: 432
Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.
Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.
With its distinguished editor and international team of contributors, "Injectable biomaterials" is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians.
Key features:
- comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology
- reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites
- explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
- addresses the issues surrounding environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility
PART 1: MATERIALS AND PROPERTIES
Designing clinically useful substitutes for the extracellular matrix
R Condie and G Prestwich, The University of Utah, USA
- Introduction: the translational challenge
- Design criteria for extracellular matrix (ECM) mimetics
- Single-module semi-synthetic extracellular matricies (sECMs) based on hyaluronic acid (HA)
- Adding function to (HA) matrices
- Using injectable extracellular matricies (sECMs) in vivo
- Conclusions and future trends
- References
Designing ceramics for injectable bone graft substitutes
M Bohner, RMS Foundation, Switzerland
- Introduction
- Rheological properties of bone substitute pastes
- Handling and delivery
- Mechanical and biological properties of bone substitute pastes
- Industrial design
- Future trends
- Sources of further information and advice
- References
Rheological properties of injectable biomaterials
R McLemore, Banner Good Samaritan Medical Center, USA
- Introduction
- Different types of in situ gelling materials: chemical gels, solvent exchange and physical gels
- Shrinkage, swelling and evaporation
- Kinetics and injectability
- The role of statistics and uncertainy in rheological characterization
- Future trends
- Sources of further information and advice
- References
Improving mechanical properties of injectable polymers and composites
Y Qiu, S Hamilton and J Temenoff, Georgia Tech/Emory University, USA
- Introduction
- Mechanical properties and testing
- Injectable hydrogels
- Non-hydrogel injectable polymers
- Conclusion and future trends
- References
PART 2: CLINICAL APPLICATIONS
Drug delivery applications of injectable biomaterials
D J Overstreet, H A von Recum and B L Vernon, Arizona State University, USA
- Introduction
- Solvent exchange precipitating materials
- Aqueous solubility change materials
- In situ crosslinking or polymerizing materials
- Microparticles and nanoparticles
- Micelles and liposomes
- Polymer-drug conjugates
- Conclusion and future trends
- References
Tissue engineering applications of injectable biomaterials
S Kona, A S Wadajkar and K T Nguyen, University of Texas at Arlington, USA
- Introduction
- Requirements of injectable materials for tissue engineering
- Injectable biomaterials: methods of gelation and tissue engineering applications
- Injectable composites and applications in tissue engineering
- Conclusion and future trends
- References
- Glossary
- List of abbreviations
Vascular applications of injectable biomaterials
B L Vernon and C Riley, Arizona State University, USA
- Introduction
- Embolization therapy for vascular conditions
- Types of embolic materials
- Future trends
- Sources of further information and advice
- References
Orthopaedic applications of injectable biomaterials
A C McLaren and C S Estes, Banner Good Samaritan Medical Center, USA
- Introduction
- Classification
- Clinical applications 1: fixation
- Clinical applications 2: bone healing
- Clinical applications 3: prevention and regeneration
- Clinical applications 4: miscellaneous
- Conclusion
- References
Dental applications of injectable biomaterials
R W Hasel, Stanford University School of Medicine and E Combe, University of Minnesota School of Dentistry, USA
- Introduction
- Challenges in the application of biomaterials to dentistry
- Directly-placed tooth-colored materials
- Injectable materials in root canal therapy
- Injectable calcium phosphate cements
- Conclusion
- References
Injectable polymeric carriers for gene delivery systems
C-S Cho, R B Arote, D Jere, H-L Jiang, Y-K Kim, Y-J Choi and M-H Cho, Seoul National University, Korea
- Introduction
- Biological barriers
- Nanoparticles
- Microspheres
- Hydrogel
- Small interfering ribonucleic acid (RNA) (siRNA)
- Conclusion
- Acknowledgements
- References
PART 3: TECHNOLOGIES AND DEVELOPMENTS
Environmentally responsive injectable materials
H H Bearat and B L Vernon, Arizona State University, USA
- Introduction
- Temperature-sensitive polymers
- Electrically-sensitive polymers
- pH-sensitive polymers
- Light-sensitive polymers
- Biomolecular-sensitive polymers
- Other stimuli-sensitive polymers
- Conclusion and future trends
- References
Injectable nanotechnology
F Cellesi and N Tirelli, University of Manchester, UK
- Introduction
- Route of administration and biodistribution of injectable nano-carriers
- Diagnostic applications of injectable nano-carriers
- Therapeutic applications of injectable nano-carriers
- Injectable nanomaterials as matrix precursors
- Conclusions
- References
Injectable biodegradable materials
B Jeong, Ewha Womans University, Korea
- Introduction
- Poly(ethylene glycol) (PEG) copolymers
- Poloxamer® and pluronic® gels
- Polypeptides
- Other thermogelling polymers
- Conclusions and future trends
- Acknowledgements
- References
Troubleshooting and hurdles to development of biomaterials
T A Becker, Independent Medical Device Consultant, USA
- Introduction
- Material development hurdles
- Device development hurdles
- Funding challenges
- References
Biocompatibility of injectable materials
S A Guelcher, Vanderbilt University, USA
- Introduction
- Environmentally responsive biomaterials
- Self-assembling biomaterials
- Calcium phosphate bone cements
- In situ polymerizable and crosslinkable biomaterials
- Future trends
- Sources of further information and advice
- References
Future applications of injectable biomaterials: the use of microgels as modular injectable scaffolds
R Scott, Saint Louis University and R Kuntz Willits, The University of Akron, USA
- Introduction
- Background
- Potential applications of microgels
- Conclusions
- Sources of further information and advice
- References
Brent Vernon is Associate Professor of Bioengineering at Arizona State University, USA.
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