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Muscle 2-Volume Set

Description:
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.

Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

- The only resource to focus on science before the clinical work and therapeutics
- Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions
- Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth
 
Contents:
Part 1: Introduction

1. An Introduction to Muscle

2. A History of Muscle

Part II: Cardiac Muscle

Section A: Basic Physiology

3. Cardiac Myocyte Specification and Differentiation

4. Transcriptional Control of Cardiogenesis

5. Cardiomyocyte Ultrastructure

6. Overview of CArdiac Muscle Physiology

7. Ionic Fluxes and Genesis of the Cardiac Action Potential

8. G-Protein-Coupled Receptors in the Heart

9. Receptor Tyrosine Kinases in Cardiac Muscle

10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network

11. Calcium Fluxes and Homeostasis

12. Excitation-Contraction Coupling in the Heart

13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle

14. Cardiovascular Mechanotransduction

15. Cardiomyocyte Metabolism: All Is in Flux

16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function

17. Mitochondrial Morphology and Function

18. Genetics and Genomics in Cardiovascular Gene Discovery

19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications

Section B: Adaptations and Response

20. Adaption and Responses: Myocardial Innervations adn Neural Control

21. Regulation of Cardiac Systolic Function and Contractility

22. Intracellular Signaling Pathways in Cardiac Remodeling

23. Oxidative Stress and Cardiac Muscle

24. Physiologic and Molecular Responses of the Heart to Chronic Exercise

25. Epigenetics in Cardiovascular Biology

26. Cardiac MicroRNAs

27. Protein Quality Control in Cardiomyocytes

28. Cardioprotection

29. Cardiac Fibrosis: Cellular and Molecular Determinants

30. Autophagy in Cardiac Physiology and Disease

31. Programmed Cardiomyocyte Death in Heart Disease

32. Wnt and Notch: Potent Regulators of Cardiomyocyte Specification, Proliferation, and Differentiation

Section C: Myocardial Disease

33. Congenital Cardiomyopathies

34. Genetics of Congenital Heart Disease

35. Mechanisms of Stress-Induced Cardiac Hypertrophy

36. Ischemic Heart Disease

37. The Pathophysiology of Heart Failure

38. The Right Ventricle: Reemergence of the Forgotten Ventricle

39. Mammalian Myocardial Regeneration

40. The Structural Basis of Arrhythmia

41. Molecular and Cellular Mechanisms of Cardiac Arrhythmias

42. Genetic Mechanisms of Arrhythmia

43. Infiltrative adn Protein Misfolding Myocardial Diseases

44. Cardiac Aging: From Humans to Molecules

45. Adrenergic Receptor Polymorphisms in Heart Failure

46. Cardiac Gene Therapy

47. Protein Kinases in the Heart: Lessons Learned from Targeted Cancer Therapeutics

48. Cell Therapy for Cardiac Disease

49. Chemical Genetics of Cardiac Regeneration

50. Device Therapy for Systolic Ventricular Failure

51. Novel Therapeutic Targets and Strategies against Myocardial Diseases

Part III: Skeletal Muscle

Section A: Basic Physiology

52. Skeletal Muscle Development

53. Skeletal Muscle: Architecture of Membrane Systems

54. The Vertebrate Neuromuscular Junction

55. Neuromuscular Interactions that Control Muscle Function and Adaptation

56. Control of Resting CA2+ Concentration in Skeletal Muscle

57. Skeletal Muscle Excitation-Contraction Coupling

58. The Contractile Machinery of Skeletal Muscle

59. Skeletal Muscle Metabolism

60. Skeletal Muscle Fiber Types

Section B: Adaptations and Response

61. Regulation of Skeletal Muscle Development and Function by microRNAs

62. Musculoskeletal Tissue Injury and Repair: Role of Stem Cells, Their Differentiation, and Paracrine Effects

63. Immunological Responses to Muscle Injury

64. Skeletal Muscle Adaptation to Exercise

65. Skeletal Muscle Regeneration

66. Skeletal Muscle Dystrophin-Glycoprotein Complex and Muscular Dystrophy

Section C: Skeletal Muscle Disease

67. Statin-Induced Muscle Toxicity: Clinical and Genetic Determinants of Risk

68. Myotonic Dystrophy

69. Facioscapulohumeral Muscular Dystrophy: Unraveling the Mysteries of a Complex Epigenetic Disease

70. ECM-Related Myopathies and Muscular Dystrophies

71. Molecular Pathogenesis of Skeletal Muscle Abnormalities in Marfan Syndrome

72. Diseases of the Nucleoskeleton

73. Channelopathies of Skeletal Muscle Excitability

74. Thick and Thin Filament Proteins: Acquired adn Hereditary Sarcomeric Protein Diseases

75. Metabolic and Mitochondrial Myopathies

Section D: Therapeutics

76. Gene Therapy of Skeletal Muscle Disorders Using Viral Vectors

77. Cell-Based Therapies in Skeletal Muscle Disease

78. Immunological Components of Genetically Inherited Muscular Dystrophies: Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy

79. Myostatin: Regulation, Function, and Therapeutic Applications

80. Insulin-Like Growth Factor I Regulation and Its Action in Skeletal Muscle Growth and Repair

81. Novel Targets and Approaches to Treating Skeletal Muscle Disease

Part IV: Smooth Muscle

Section A: Basic Physiology

82. Development of the Smooth Muscle Cell Lineage

83. Smooth Muscle Myocyte Ultrastructure

84. Potassium, Sodium, and Chloride Channels in Smooth Muscle Cells

85. G-Protein-Coupled Receptors in Smooth Muscle

86. Calcium Homeostasis and Signaling in Smooth Muscle

87. Regulation of Smooth Muscle Contraction

Section B: Heterogeneities

88. Heterogeneity of Smooth Muscle

89. Microcirculation

90. Uterine Smooth Muscle

Section C: Adaptations and Response

91. Oxidative Stres, Endothelial Dysfunction, and Its Impact on Smooth Muscle Signaling

92. Hemodynamic Control of Vascular Smooth Muscle Function

93. Myogenic Tone and Mechanotransduction

94. Cell-Cell Communication Through Gap Junctions

95. Vascular Smooth Muscle Cell Phenotypic Adaptation

96. Molecular Pathways of Smooth Muscle Disease

Section D: Smooth Muscle Disease

97. Genetic Variants in Smooth Muscle Contraction and Adhesion Genes Cause Thoracic Aortic Aneurysms and Dissections and Other Vascular Diseases

98. Vascular Smooth Muscle Cell Remodeling in Atherosclerosis and Restenosis

99. Arterial Hypertention

100. Diabetic Vascular Disease

101. Vascular Mechanisms of Hypertension in the Pathophysiology of Preeclampsia

102. Erectile Dysfunction

103. Smooth Muscle in the Normal and Diseased Pulmonary Circulation

104. Airway Smooth Muscle and Asthma

105. Aging

106. Vascular Calcification

107. Smooth Muscle Progenitor Cells: A Novel Target for the Treatment of Vascular Disease?

108. Smooth Muscle: Novel Targets and Therapeutic Approaches
 
Authors
Hill, Joseph
Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure.
Olson, Eric
Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.
 
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