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Foldamers. Structure, Properties and Applications

  • ID: 2179712
  • May 2007
  • 456 Pages
  • John Wiley and Sons Ltd
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This truly comprehensive treatise of foldamers, ranging from synthesis to applications in bio–,material, and nanoscience, is both an introduction to the topic, while also providing in depth accounts on various aspects aimed specifically at the specialist.

The book is clearly structures, with the firs part concentrating on structure and foldamer design concepts, while the second part covers functional aspects from properties to applications. The international team of expert authors provides up–to–date overviews of this rapidly expanding and highly interdisciplinary field.

From the foreword by Francios Diederich, Swiss Federal Institute of Technology (ETH), Zurich: "I strongly recommend this monograph to all academic and industrial researchers interest in fascinating perspectives for future chemical research; it will also take its place in modern graduate student education."

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Foreword

STRUCTURE: FOLDAMER DESIGN CONCEPTS

Foldamers Based on Local Conformation Preferences

Foldamers Based on Remote Intrastrand Interactions

Foldamers Based on Solvophobic Effects

Foldamer Hybrids: Defined Supramolecular Structures from Flexible Molecules

Control of Polypeptide Chain Folding and Assembly

Simulation of Folding Equilibria

FUNCTION: FROM PROPERTIES TO APPLICATIONS

Foldamer–based Molecular Recognition

Biological Application of Foldamers

Protein Design

Nucleic Acid Foldamers: Design, Engineering and Selection of Programmable Biomaterials with Recognition, Catalytic and Self–assembly Properties

Helically Folding Polymers

Polyisocyanides: Stiffened Foldamers

Foldamers at Interfaces

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Hecht and Huc have made an important contribution to the literature of foldamers. The greatest strength of their volume is that it presents the diversity and open–ended possibilities offoldamer–based research, rather than trying to rigidly categorize the field. Chemists from all subdisciplines will find it an inspiring invitation to join in solving the challenges and exploiting the potential of this fascinating arena of molecular science.   (JACS, 2008)

"Anyone who considers joining this field, or who just wants to know what is being done in the area, will be fortunate to have the efforts of editors Hecht and Huc at hand." (
Angewandte Chemie International Edition, January 2008)

" Foldamers is a delightful treatise on the subject area, provided that the reader is bent towards the biological realm. Such versatility is hard to find, and the authors and editors should be commended for their hard work." (ChemMedChem, December 2007)

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