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Molecular System Bioenergetics. Energy for Life

  • ID: 2179758
  • September 2007
  • 633 Pages
  • John Wiley and Sons Ltd
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Every organism must consume energy to survive. The food we eat is ultimately converted into chemical fuel for our cells, and the availability (or non–availability) of these fuels determines whether cells may grow and divide or starve and die. Not surprisingly, the energy metabolism is a key factor in sustaining or blocking the unlimited growth of cancer cells.

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic.

Following an introduction, they go on to discuss the basic principles, organization and dynamics of cellular energetics, as well as energy transfer networks, metabolic feedback regulation and modeling, finishing off with a section on applied molecular system bioenergetics.

With its combination of systems biology and cellular energetics, this is an invaluable reference for biochemists, biophysicists, cell and molecular biologists, as well as bioengineers.

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Introduction

MOLECULAR SYSTEM BIOENERGETICS: BASIC PRINCIPLES, ORGANISATION AND DYNAMICS OF CELLULAR ENERGETICS

Cellular Energy Metabolism and Integrated Oxidative Phosphorylation

Organization and Regulation of Mitochondrial Oxidative Phosphorylation

Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation and Metabolic Channeling

On the Network Properties of Mitochondria

Structural Organization and Dynamics of Mitochondria in the Cells In Vivo

ENERGY TRANSFER NETWORKS, METABOLIC FEEDBACK REGULATION AND MODELING OF CELLULAR ENERGETICS

Mitochondrial VDAC and its Complexes

Phospho–Creatine Circuit:

Integration of Adenylate Kinase, Glycolytic and Glycogenolytic Circuits in Cellular Energetics

Signaling by AMP–Activated Protein Kinase

Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase Deficient Mice

System Analysis of Cardiac Energetics –

Excitation–Contraction Coupling

Principles of Mathematical Modeling and In Silico Studies of Integrated Systems of Cellular Energetics

Modeling Energetics of Ion Transport, Membrane Sensing and System Biology of the Heart

APPLIED MOLECULAR SYSTEM BIOENERGETICS

Mitochondrial Adaptation to Exercise and Training –

A Physiological Approach

Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology

Tumour Cell Energetic Metabolome

AMPK and the Metabolic Syndrome

A Systems Biology Perspective of Obesity and Type 2 Diabetes

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Valdur Saks is Professor of Bioenergetics and Biochemistry at the University of Grenoble, France, and Head of the Laboratory of Bioenergetics at the National Institute of Chemical and Biological Physics in Tallinn, Estonia. A graduate of Moscow University, he was the long–time head of the Laboratory of Cardiac Bioenergetics in Moscow, Russia, before taking up his present positions. Professor Saks has authored over 220 scientific publications and has received numerous scientific awards, including the USSR State Prize in Science and the Internatinoal "Research and Development" Award sponsored by the U.N. and UNICEF. He is a member of the International Society for Heart Research and of the American Physiological and Biophysical Societies.

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