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Modern Biopharmaceuticals. Recent Success Stories - Product Image

Modern Biopharmaceuticals. Recent Success Stories

  • Published: April 2013
  • Region: Global
  • 800 Pages
  • John Wiley and Sons Ltd

This collection of high-profile contributions provides a unique insight into the development of novel, successful biopharmaceuticals.

Outstanding authors, including Nobel laureate Robert Huber as well as prominent company researchers and CEOs, present valuable insider knowledge, limiting their scope to those procedures and developments with proven potential for the biotechnology industry. They cover all relevant aspects, from the establishment of biotechnology parks, the development of successful compounds and the implementation of efficient manufacturing processes, right up to the establishment of advanced delivery routes.

Members of the Working Group for Excavations V

Preface VII

Notes for the User XI

1 Introduction 1

1.1 Engineering prerequisites for applying the Recommendations (R l) 1

1.2 Governing regulations (R 76) 1

1.3 Safety factor approach (R 77) 4

1.4 Limit states (R 78) 6

1.5 Support of retaining walls (R 67) 9

1.6 Planning and examination of excavations (R 106) 10

2 Analysis principles 11

2.1 Actions (R 24) 11

2.2 Determination of soil properties (R 2) 13

2.3 Earth pressure angle (R 89) 15

2.4 Partial safety factors (R 79) 17

2.5 General requirements for adopting live loads (R 3) 18

2.6 Live loads from road and rail traffic (R 55) 20

2.7 Live loads from site traffic and site operations (R 56) 23

2.8 Live loads from excavators and lifting equipment (R 57) 24

3 Magnitude and distribution of earth pressure 29

3.1 Magnitude of earth pressure as a function of the selected construction method (R 8) 29

3.2 Magnitude of total active earth pressure lead without surcharge loads (R 4) 30

3.3 Distribution of active earth pressure without surcharges (R 5) 34

3.4 Magnitude of total active earth pressure lead from live loads (R 6) 37

3.5 Distribution of active earth pressure from live loads (R 7) 39

3.6 Superimposing earth pressure components with surcharges (R 71) 42

3.7 Determination of at-rest earth pressure (R 18) 44

3.8 Earth pressure in retreating states (R 68) 46

4 General stipulations for analysis 49

4.1 Stability analysis (R 81) 49

4.2 General information on analysis methods (R 11) 51

4.3 Determination and analysis of embedment depth (R 80) 54

4.4 Determination of action effects (R 82) 58

4.5 Modulus of subgrade reaction method (R 102) 61

4.6 Finite-element method (R 103) 66

4.7 Analysis of the vertical component of the mobilized passive earth pressure (R 9) 71

4.8 Analysis of the transfer of vertical forces into the subsurface (R 84) 73

4.9 Stability analyses for braced excavations in special cases (R 10) 76

4.10 Serviceability analysis (R 83) 78

4.11 Allowable simplifications in limit states GEO 2 or STR (R 104) 82

5 Analysis approaches for soldier pile walls 85

5.1 Determination of load models for soldier pile walls (R 12) 85

5.2 Pressure diagrams for supported soldier pile walls (R 69) 87

5.3 Soil reactions and passive earth pressure for soldier pile walls with free earth supports (R 14) 89

5.4 Fixed earth support for soldier pile walls (R 25) 91

5.5 Equilibrium of horizontal forces for soldier pile walls (R 15) 94

6 Analysis approaches for sheet pile walls and in-situ concrete walls 99

6.1 Determination of load models for sheet pile walls and in-situ concrete walls (R 16)99

6.2 Pressure diagrams for supported sheet pile walls and in-situ concrete walls (R 70)101

6.3 Ground reactions and passive earth pressure for sheet pile walls and in-situ concrete walls with free earth support
(R 19) 103

6.4 Fixed earth support for sheet pile walls and in-situ concrete walls (R 26) 106

7 Anchored retaining walls 111

7.1 Magnitude and distribution of earth pressure for anchored retaining walls (R 42) 111

7.2 Analysis of force transfer from anchors to the ground (R 43) 112

7.3 Verification of stability at the lower failure plane (R 44) 113

7.4 Analysis of overall stability (R 45) 119

7.5 Measures to counteract deflections in anchored retaining walls (R 46) 122

8 Excavations with special ground plans 125

8.1 Excavations with circular plan (R 73) 125

8.2 Excavations with oval plan (R 74) 130

8.3 Excavations with rectangular plan (R 75) 137

9 Excavations adjacent to structures 143

9.1 Engineering measures for excavations adjacent to structures (R 20) 143

9.2 Analysis of retaining walls with active earth pressure for excavations adjacent to structures (R 21) 145

9.3 Active earth pressure for large distances to structures (R 28) 147

9.4 Active earth pressure for small distances to structures (R 29) 149

9.5 Analysis of retaining walls with increased active earth pressure (R 22) 151

9.6 Analysis of retaining walls with at-rest earth pressure (R 23) 155

9.7 Mutual influence of opposing retaining walls for excavations adjacent to structures (R 30) 159

10 Excavations in water 163

10.1 General remarks on excavations in water (R 58) 163

10.2 Flow forces (R 59) 165

10.3 Dewatered excavations (R 60) 166

10.4 Analysis of hydraulic heave safety (R 61) 168

10.5 Analysis of buoyancy safety (R 62) 172

10.6 Stability analysis of retaining walls in water (R 63) 179

10.7 Design and construction of excavations in water (R 64) 183

10.8 Water management (R 65) 186

10.9 Monitoring excavations in water (R 66) 188

11 Excavations in unstable rock mass 189

11.1 General recommendations for excavation in unstable rock mass (R 38) 189

11.2 Magnitude of rock mass pressure (R 39) 192

11.3 Distribution of rock pressure (R 40) 194

11.4 Bearing capacity of rock mass for support forces at the embedment depth (R 41) 195

12 Excavations in soft soils 197

12.1 Scope of Recommendations R 91 to R 101 (R 90) 197

12.2 Slopes in soft soils (R 91) 198

12.3 Wall types in soft soils (R 92) 200

12.4 Construction procedure in soft soils (R 93) 204

12.5 Shear strength of soft soils (R 94) 208

12.6 Earth pressure on retaining walls in soft soils (R 95) 213

12.7 Ground reactions for retaining walls in soft soils (R 96) 217

12.8 Water pressure in soft soils (R 97) 222

12.9 Determination of embedment depths and action effects for excavations in soft soils (R 98) 228

12.10 Additional stability analyses for excavations in soft soils (R 99) 230

12.11 Water management for excavations in soft soils (R 100) 234

12.12 Serviceability of excavation structures in soft soils (R 101) 235

13 Analysis of the bearing capacity of structural elements 239

13.1 Material parameters and partial safety factors for structural element resistances (R 88) 239

13.2 Bearing capacity of soldier pile infilling (R 47) 240

13.3 Bearing capacity of soldier piles (R 48) 243

13.4 Bearing capacity of sheet piles (R 49) 246

13.5 Bearing capacity of in-situ concrete walls (R 50) 248

13.6 Bearing capacity of waling (R 51) 250

13.7 Bearing capacity of struts (R 52) 251

13.8 Bearing capacity of trench lining (R 53) 254

13.9 Bearing capacity of provisional bridges and excavation covers (R 54) 255

13.10 External bearing capacity of soldier piles, sheet pile walls and in-situ concrete walls (R 85) 257

13.11 Bearing capacity of tension piles and ground anchors (R 86) 259

14 Measurements and monitoring on excavation structures 261

14.1 Purpose of measurements and monitoring (R 31) 261

14.2 Measurands and measuring methods (R 32) 262

14.3 Measurement planning (R 33) 264

14.4 Location of measuring points (R 34) 266

14.5 Carrying out measurements and forwarding measurement results (R 35) 267

14.6 Evaluation and documentation of measurement results (R 36) 268

Annex 271

Bibliography 287

Terms and notation 299

Recommendations in numerical order 303

Dr. Jörg Knäblein studied Biotechnology / Chemical Engineering at the Society for Biotechnology Research (GBF) in Braunschweig, Germany and Biochemistry at the Max-Planck-Institute for Biochemistry. He received his Ph.D. from the Max-Planck-Institute for Biochemistry in Martinsried / Munich where he worked in the group of Professor Robert Huber (Nobelprize laureate in 1988). Jörg Knäblein holds a leading position in technology scouting at Bayer Schering Pharma AG, Berlin.. . . AWARDS:. Riedel-de Haen-Stiftung. Government / Ministry of Science. Nomination for the Max-Buchner-Award from DECHEMA (Society for Biotechnology and Chemical Engineering). Winner of the McKinsey business plan contest

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