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Biochemical Engineering. A Textbook for Engineers, Chemists and Biologists

  • ID: 2179979
  • October 2009
  • 282 Pages
  • John Wiley and Sons Ltd
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Biochemical engineering focuses on the design and construction of unit processes that involve biological organisms or molecules. It is increasingly taught as a separate discipline and as a supplementary option to chemical or biological engineering due to the similarities in both the background subject curriculum and problem–solving techniques. Its applications are to be found in the food, feed, pharmaceutical, biotechnology, and water treatment industries.

Written by renowned professors drawing on their experience gained in the world's most innovative biotechnology market, Japan, this advanced textbook provides an excellent and comprehensive introduction to the latest developments in the field.

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PART I: Basic Concepts and Principles

INTRODUCTION

Background and Scope

Dimensions and Units

Intensive and Extensive Properties

Equilibria and Rates

Batch vs. Continuous Operation

Material Balance

Energy Balance

ELEMENTS OF PHYSICAL TRANSFER PROCESSES

Introduction

Heat Conduction and Molecular Diffusion

Fluid Flow and Momentum Transfer

Laminar vs. Turbulent Flow

Transfer Phenomena in Turbulent Flow

Film Coefficients of Heat and Mass Transfer

CHEMICAL AND BIOCHEMICAL KINETICS

Introduction

Fundamental Reaction Kinetics

CELL KINETICS

Introduction

Cell Growth

Growth Phases in Batch Culture

Factors Affecting Rates of Cell Growth

Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF)

PART II: Unit Operations and Apparatus for Bio–Systems

HEAT TRANSFER

Introduction

Overall Coefficients U and Film Coefficients h

Mean Temperature Difference

Estimation of Film Coefficients h

Estimation of Overall Coefficients U

MASS TRANSFER

Introduction

Overall Coefficients K and Film Coefficients k of Mass Transfer

Types of Mass Transfer Equipment

Models for Mass Transfer at the Interface

Liquid Phase Mass Transfer with Chemical Reactions

Correlations for Film Coefficients of Mass Transfer

Performance of Packed Column

BIOREACTORS

Introduction

Some Fundamental Concepts

Bubbling Gas–Liquid Reactors

Mechanically Stirred Tanks

Gas Dispersion in Stirred Tanks

Bubble Columns

Airlift Reactors

Packed–Bed Reactors

Microreactors

MEMBRANE PROCESSES

Introduction

Dialysis

Ultrafiltration

Microfiltration

Reverse Osmosis

Membrane Modules

CELL–LIQUID SEPARATION AND CELL DISRUPTION

Introduction

Conventional Filtration

Microfiltration

Centrifugation

Cell Disruption

STERILIZATION

Introduction

Kinetics of Thermal Death of Cells

Batch Heat Sterilization of Culture Media

Continuous Heat Sterilization of Culture Media

Sterilizing Filtration

ADSORPTION AND CHROMATROGRAPHY

Introduction

Equilibria in Adsorption

Rates of Adsorption into Adsorbent Particles

Single– and Multi–Stage Processes for Adsorption

Adsorption in Fixed Beds

Separation by Chromatography

PART III: Practical Aspects in Bioengineering

FERMENTOR ENGINEERING

Introduction

Stirrer Power Requirements for Non–Newtonian Liquids

Heat Transfer in Fermentors

Gas–Liquid Mass Transfer in Fermentors

Criteria for Scaling–Up Fermentors

Modes of Fermentor Operation

Fermentors for Animal Cell Culture

DOWNSTREAM OPERATIONS IN BIOPROCESSES

Introduction

Separation of Microorganisms by Filtration and Microfiltration

Separation by Chromatography

Separation in Fixed Beds

Sanitation in Downstream Processes

MEDICAL DEVICES

Introduction

Blood and Its Circulation

Oxygenation of Blood

Artificial Kidney

Bioartificial Liver

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Prof. Shigeo Katoh is Head of the Bioengineering Laboratory at Kobe University, Japan. He holds PhD in Chemical Engineering from the University of Kyoto, Japan. Prof. Katoh is an enthusiastic lecturer in Biochemical Engineering, Bioseparation Engineering and Immunotechnology. He is an outstanding expert in biochemical engineering and has published numerous papers in this field.
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. Prof. em. Fumitake Yoshida was one of the world's most respected chemical engineers. Most recently he was professor emeritus of chemical engineering at Kyoto University and well beyond his retirement he continued to be a visiting lecturer at universities around the world. He conducted research on various mass transfer operations, gas–liquid systems in particular, investigating their applications in bioengineering and medical technology. Yoshida received his BS and PhD degrees in engineering from Kyoto University. Among his many awards and citations was election to the National Academy of Engineering of the United States in 1979 for his leadership in chemical, biochemical, and biomedical engineering in Japan.
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