Modern Biophysical Chemistry

John Wiley and Sons Ltd, February 2009, Pages: 310

The only introductory text to address contemporary methods, the really interesting stuff to spice up a standard biophysics course is to be found here. Accessible and didactically written, it is based on a graduate course taught by the author for several years. By presenting a mix of basic theory and real life application examples, he successfully bridges the gap between theory and experiment.
Divided into two major parts, this advanced textbook explains all relevant methods used in current industrial research. The first part, basic biophysical chemistry, surveys basic spectroscopic techniques and properties that are the prerequisite for the more sophisticated technologies discussed in the remainder of the book. The second part covers modern, cutting-edge bioanalytical techniques based on physical methods, such as confocal fluorescence, ultrafast spectroscopy, optical tweezers, single molecule electrical measurements, quantum dots, and single molecule force microscopy. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented.

Introduction: What is Biophysical Chemistry?

PART 1: BASIC METHODS IN BIOPHYSICAL CHEMISTRY
Basic Optical Principles
Optical Properties of Biomolecules
Basic Fluorescence Techniques
Chiroptical and Scattering Methods
Magnetic resonance techniques
Mass spectrometry

PART 2: ADVANCED METHODS IN BIOPHYSICAL CHEMISTRY
Fluorescene Microscopy
Single-Biomolecule Techniques
Ultrafast and Nonlinear Spectroscopy
Special Techniques
Assay Development, Readers and High-Throughput Screening

?The book is strong on the basics, with appropriate treatments of fundamental molecular spectroscopy leading on to more recent application in single-molecule manipulation and analysis.? (Chemistry World, August 2009)

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