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07 - 2012 Emerging Medical Technologies Spotlight: A Report of Investment & Partnering Opportunities

Life Science Intelligence, July 2012

This report includes details on 30 emerging medical technology companies that have been identified by LSI's in-house research team in July 2012.

All companies include technology, market(s), key executive, and contact information.

Coverage includes innovations in a broad spectrum of medical technology areas including:

- Aesthetics/Dermatology Companies
- Biomaterials Companies
- Biotechnology/Cell Therapy Companies
- Cardiovascular Companies
- Dental Companies
- Diagnostics Companies
- Drug Delivery Companies
- Endocrine Companies
- Gastroenterology Companies
- Gynecology/Women's Health Companies
- Imaging Companies
- Neurology Companies
- Oncology Companies
- Ophthalmology Companies
- Orthopedics Companies
- Pain Management Companies
- Patient Management/Monitoring Companies
- Pharmaceutical Companies
- Respiratory Companies
- Spine Companies
- Surgery Companies
- Urology Companies
- Vascular Companies
- Wound Management Companies

Brief Technology Descriptions For Companies Covered

- Fatty acid synthase (FASN) inhibitors with pharmaceutical properties that overcome the shortcomings of earlier generations of inhibitors, for the treatment of chronic hepatitis C virus (HCV) and pancreatic, prostatic, breast, and colorectal tumors

- A custom fit, rehabilitative body suit that offers instantaneous back pain relief, trains and conditions the body to prevent or rehabilitate from back injuries, and increases the overall long-term health of the spine

- Biomaterial and regenerative medicine products for ophthalmological applications: ologen(R) Collagen Matrix, BioCornea, and Biolens

- First-in-class, small molecule compounds that successfully manage and treat chronic pain, by inhibiting P2X3 receptors

- Biomaterials for post-surgical adhesion prevention, scar prevention, wound care, and tissue reconstruction

- Micro-catheter platform that uses a proprietary microfluidic design for the delivery of drug/active molecules directly to the central nervous system for the treatment of difficult/chronic neurological conditions

- Protein therapeutics with extremely high target binding specificity for the treatment of cancer and immune-mediated diseases

- An antibody that blocks the calcitonin gene-related peptide (CGRP) pathway to prevent migraine headaches

- Drugs for the treatment of depression, anxiety, epilepsy, pain, glaucoma, spasticity, and a variety of other CNS-related conditions

- Nanopharmaceuticals optimized to make drugs more effective and with fewer side effects

- Ocular microinjection platform for non-surgical, targeted delivery of drugs and proteins into the suprachoroidal space

- Biology and chemistry platforms for the development of small molecule drugs to stop Alzheimer's disease and other CNS-related conditions

- New generation of fully recombinant, protease-activated monoclonal antibodies that can achieve unprecedented levels of tissue-specific targeting

- A recombinant protein to treat X-linked Hypohidrotic Ectodermal Dysplasia (XLHED), a rare genetic disorder that can be life-threatening

- Minimally invasive, image-guided breast biopsy and tissue removal technologies

- Products that support transcatheter interventions for the heart

- Non-invasive series of genetic tests, designed to offer valuable insights into the biology of patients with mood disorders and to support the development of personalized medicine

- New avenue of nucleotide therapeutic drug discovery via modulation of cellular miRNA to treat a wide range of diseases, including cancer, fibrosis, inflammation, and infectious and degenerative diseases

- Diagnostic tests for the early identification of newborns suffering from critical oxygen supply deficit during birth (Asphyxia), a major cause for brain injury, often followed by life-long disability

- A device that enables surgeons to check for remaining cancer cells at the tumor site, immediately following surgical removal of the tumor

- The first vaccine to demonstrate efficacy in reducing the mortality of otherwise highly lethal bloodstream infections due to either Candida or S. aureus (including MRSA)

- Drugs to improve health for patients by modulating disease-associated long non-coding RNA (lncRNA), thereby restoring normal expression of individual targeted genes

- Neuromonitoring devices to prevent nerve damage in all types of surgical procedures

- Novel technology for the treatment of acne

- Fully synthetic and targeted vaccines that induce an antigen-specific immune activation or an antigen-specific immune tolerance for therapeutic and prophylactic applications

- Technology that will allow hospitals to consolidate the multiple types of infusion pumps used throughout their organization into a single type of device

- A laser procedure that removes the brown pigment (melanin) from the top layer of the iris, in order to change human eye color (to blue) permanently

- Decision support software, integrated with vital sign monitoring equipment in hospital ICUs/EDs, to provide novel insights into a patient's current status and future trajectory

- Revolutionary topical antifungal with: exceptional potency, the ability to penetrate the nail, a dual mode of action, and exemplary safety profile

- Unique diagnostic and monitoring technologies:

1-"Smart Optic Capillaroscope" for non-invasive diagnostics of early disorders in the smallest vessels-capillaries

2-"Hemodynamic Lab" for simultaneous diagnostics of the whole vascular system

3-"Meteolaboratory with Feedback Effect" for controlling influence of meteorological factors on the human organism

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