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Chemical Genomics - Commercial Applications in Drug Discovery and Development


Description: The time, cost, and complexity of the process of drug discovery can be drastically reduced through the application of chemical genomics and chemogenomics. The understanding and identification of the roles of chemistry and biology early in the development process will lessen not only the time of pre-clinical development, but also the risk of late clinical development failure. To achieve this acceleration of the processes, chemical genomics/chemogenomis integrates the latest developments in tools and technologies from a variety of disciplines; including combinatorial chemistry, informatics, synthetic chemistry, cell-based assays, microarrays, genomics, bioinformatics, toxicogenomics, and proteomics.

Key Reasons to Buy

1. Get a clear definition of chemical genomics and chemogenomics via an in-depth review of their current usage and applications adopted by several companies.
2. Understand the current intellectual property landscape from a detailed summary of chemical genomics/chemogenomics patents.
3. Gain reliable and thought-provoking insights into the chemical genomics/chemogenomics forecast through interviews with industry experts.
4. Look inside companies working within the chemical genomics and chemogenomics markets, including their product pipelines, partnerships & alliances, business strategies, technologies, and more.

Report Scope

The Chemical Genomics Report provides an in-depth analysis of the promising market for chemical genomics and chemogenomics. The Report thoroughly examines chemical genomics and chemogenomics, their potential applications in the development of therapeutics for human diseases, and recent technology advancements. In addition, the intellectual property landscape is summarized, companies invested in chemical genomics and chemogenomics are profiled, and key industry players are interviewed

Market Opportunities

- Utilize chemical genomics/chemogenomics to significantly reduce the time and cost of the drug discovery cycle.
- Employ chemical genomics/chemogenomics early in the drug development process in order to reduce the time, cost, and attrition associated with it.
- Integrate multiple discovery tools and technologies for chemical genomics in order to lessen the risks, costs, and time coupled with drug discovery and development.

Company Profiles

Acadia Pharmaceuticals
Amphora Discovery Corp
Astex
ChemGenex Therapeutics
ComGenex International
Graffinity Pharmaceuticals
Iconix Pharmaceuticals
Infinity Pharmaceuticals
Morphochem
NeoGenesis
Vertex Pharmaceuticals


Contents: 1 Executive Summary

2 Introduction to Drug Discovery and Development

Drug Discovery and Development: A Complex Process
Drug Discovery and Development: A Lengthy Process
Drug Discovery and Development: An Expensive Process
Drug Discovery and Development: Bottlenecks
Preclinical/Discovery Bottlenecks
Clinical/Drug Development Bottlenecks

3 The Role of Chemistry in Chemical Genomics/Chemogenomics

Chemistry is Critical to Unlocking the Potential of Genomics
Advantages of Small Molecules

4 Defining Chemical Genomics

Major Definitions of Chemical Genomics
Classical Genetics to Chemical Genomics
Forward Genetics
Reverse Genetics

5 Chemical Genomics/ChemoGenomics Companies and Their Technologies

Acadia Pharmaceuticals
Amphora Discovery Corp.
Avalon Pharmaceuticals
Astex
ChemGenex Therapeutics
Graffinity Pharmaceuticals
Iconix Pharmaceuticals
Infinity Pharmaceuticals
Morphochem
NeoGenesis
Vertex Pharmaceuticals

6 Applying Chemical Genomics in Anti-Cancer Drug Discovery and Development

7 The ChemBank Connection

8 Events Leading to Chemical Genomics and Chemogenomics

9 Role of Chemistry in Chemical Genomics

Use of Small Molecules to Explore Biology
Examples of Utilizing Chemical Genomic and Chemogenomic Approaches
Utilizing Yeast Deletion Strains in Chemical Genomics
Imperative Tools for Successful Chemical Genomics and Chemogenomics
Applying Combinatorial and Synthesis Chemistry in Chemical Genomics
Chemical Genetics
Examples of Application of Probing Biology with Chemistry
Small-Solecule Dimerizers
TOR and the Nutrient Response-Signaling Network
HDACs and Chromatin
Summary and Conclusions

10 Opinions from Industry Experts

Reinhard Ebner, Ph.D., Principal Scientist, Avalon Pharmaceuticals
Bill Heilman, PhD, Chief Operating Officer, Comgenex International
Alan Engelberg, Vice President, Product Management, Iconix Pharmaceuticals, Inc.
Martin F. Haslanger, Ph.D., President and Chief Executive Officer, Amphora Discovery Corporation
Guri Giaever, Stanford Genome Technology Center
Andrew W. Stern, Ph.D., VP, Molecular and Cell Biology, Infinity Pharmaceuticals

11 Company Profiles

Acadia Pharmaceuticals
Amphora Discovery Corp
Astex
ChemGenex Therapeutics
ComGenex International
Graffinity Pharmaceuticals
Iconix Pharmaceuticals
Infinity Pharmaceuticals
Morphochem
NeoGenesis
Vertex Pharmaceuticals

12 Recommended Reading




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