Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that Ypt/Rab proteins play in vesicular transport steps, including vesicle budding, movement, and fusion. In recent years, Ypt/Rab GTPases and membrane trafficking have been discovered to play an important role in other cellular processes, such as signal transduction, cell growth and differentiation. Additionally, Rab GTPases have been implicated in various human diseases, ranging from diabetes to cancer.
This e-book provides a timely update on the rapidly developing field and discusses all functional aspects of Ypt/Rab GTPases. The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases. A comprehensive picture about how each Ypt/Rab controls multiple vesicular trafficking steps via interactions with multiple effectors is conveyed to the reader’s mind.
This e-book is the first ever volume focused on the Ypt/Rab GTPases and should provide a useful resource for researchers, students and teachers interested in the field.
This e-book provides a timely update on the rapidly developing field and discusses all functional aspects of Ypt/Rab GTPases. The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases. A comprehensive picture about how each Ypt/Rab controls multiple vesicular trafficking steps via interactions with multiple effectors is conveyed to the reader’s mind.
This e-book is the first ever volume focused on the Ypt/Rab GTPases and should provide a useful resource for researchers, students and teachers interested in the field.
Table of Contents
Foreword iPreface ii
List of Contributors iii
CHAPTERS
1. Ypt/Rab GTPases and Intracellular Membrane Trafficking: An Overview 3
Guangpu Li and Nava Segev
2. The Golgi Gatekeepers: Ypt1-Rab1 and Ypt31/32-Rab11 18
David Taussig, Shu H. Chen and Nava Segev
3. Rab6 GTPase 34
Bruno Goud and Anna Akhmanova
4. Polarized Exocytosis in Yeast: Sec4p 47
Andreas Knödler, Vishnu Ganesan and Wei Guo
5. Masterclass with Rab3 and Rab27: Orchestrating Regulated Secretion 55
François Darchen and Claire Desnos
6. Function of Rab27a in Melanocytes and Cytotoxic T Lymphocytes 77
John A. Hammer III and Xufeng Wu
7. Early Endocytosis: Rab5, Rab21 and Rab22 93
Guangpu Li
8. Role of Rab4 in Transport through the Endosomal System 108
Emma Martinez Sanchez, Ioana Popa, Magda Deneka and Peter van der Sluijs
9. Rab11a, Rab8a and Myosin V: Regulators of Recycling and Beyond 123
James R. Goldenring, Joseph T. Roland and Lynne A. Lapierre
10. Role of Rab7/Ypt7 in Organizing Membrane Trafficking At the Late Endosome 132
Mirjana Nordmann, Christian Ungermann and Margarita Cabrera
11. Transport from Late Endosomes to the Golgi: Rab9 GTPase 144
Eric J. Espinosa and Suzanne R. Pfeffer
12. Novel Rab GTPases 155
Maria Luisa Rodrigues and José B. Pereira-Leal
Index 169
