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Stem Cells, Craniofacial Development and Regeneration

  • ID: 2330216
  • Book
  • April 2013
  • 584 Pages
  • John Wiley and Sons Ltd
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A revealing look at the latest in craniofacial stem cell research and therapy

With their unique ability to repair and replenish adult tissues, stem cells are increasingly used in cutting–edge medical therapies. This timely work focuses on the role of stem cells in craniofacial development, exploring the rapidly evolving area of dental and craniofacial tissue regeneration.

With expert contributions from the forefront of craniofacial research and dentistry, Stem Cells in Craniofacial Development and Regeneration first introduces the development and regeneration of craniofacial tissues and organs, from neural crest cells to early tooth development. It then goes on to examine the different types of stem cells and their niches in craniofacial tissues, including what we can learn from rodent models. Concluding chapters survey the latest trends in stem cell mediated craniofacial tissue bioengineering and stem cell therapies for treating damaged or lost tissue. Stem Cells in Craniofacial Development and Regeneration:

  • Explains the mechanisms and biology of craniofacial morphogenesis and development
  • Describes bone, tooth, muscle, and temporomandibular joint (TMJ) development and regeneration
  • Covers dental, muscle, salivary gland, induced pluripotent stem cells (iPSCs), and stem cells from bone marrow and adipose tissue
  • Highlights advances in bioengineering for the repair of bone, muscle tissue, teeth, roots, and periodontal tissue
  • Offers information on biological data integration and searching

Stem Cells in Craniofacial Development and Regeneration is a must–have reference for craniofacial researchers, developmental biologists, tissue engineers, and dentists. It is also an important guide for students in dentistry and oral–maxillofacial surgery and related fields.

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Contributors xi

Preface xv


1 Molecular Blueprint for Craniofacial Morphogenesis and Development 3Paul A. Trainor

2 Cranial Neural Crest Cells in Craniofacial Tissues and Organs 31Carolina Parada and Yang Chai

3 Craniofacial Intramembranous Bone Development and Regeneration 51David P. Rice and Ritva Rice

4 Temporomandibular Joint Development 71Shuping Gu and YiPing Chen

5 Craniofacial Muscle Development 87Robert G. Kelly

6 Tooth Morphogenesis and Renewal 109Maria Jussila, Emma Juuri, and Irma Thesleff

7 Reptilian Tooth Regeneration 135Joy M. Richman, John A. Whitlock, and John Abramyan

8 Tooth Root Development 153Brian L. Foster, Francisco H. Nociti Jr., and Martha J. Somerman

9 Systems Biology of Early Tooth Development 179Daniel J. O Connell, Joshua W. K. Ho, and Richard L. Maas


10 Stem Cells, Induced Pluripotent Stem Cells, and Their Differentiation to Specified Lineage Fates 205George T.–J. Huang, Xiao–Ying Zou, Xing Yan, Kyle J. Hewitt, Yulia Shamis, and Jonathan A. Garlick

11 Bone Marrow Mesenchymal Stem Cells 223Songtao Shi and Stan Gronthos

12 Adipose Tissue Derived Stem Cells and Their Regeneration Potential 241Jeffrey Gimble, Maryam Rezai Rad, and Shaomian Yao

13 Skeletal Muscle Stem Cells: Their Origin and Niche Factors 259Johannes W. Von den Hoff and Sander Grefte

14 Stem Cells in Salivary Gland Development and Regeneration 271Isabelle M. A. Lombaert and Matthew P. Hoffman

15 Stem and Progenitor Cells of Dental and Gingival Tissue Origin 285Christian Morsczeck, George T.–J. Huang, and Songtao Shi

16 Regulation and Differentiation Potential of Dental Mesenchymal Stem Cells 303Lei Wang, Christian Morsczeck, Stan Gronthos, and Songtao Shi

17 An Incisive Look at Stem Cells: The Mouse Incisor as an Emerging Model for Tooth Renewal 315Frederic Michon, Andrew H. Jheon, Kerstin Seidel, and Ophir D. Klein

18 Mesenchymal Stem Cell Niches in Rodent Tooth Pulp 329Jifan Feng and Paul T. Sharpe


19 Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells 341Christopher S. D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares–Navarrete, Zvi Schwartz, and Barbara D. Boyan

20 Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells 367Nan Jiang, Mo Chen, Chang Hun Lee, Jian Zhou, Mildred C. Embree, Kimi Kong, Choko Cho, Avital Mendelson, Ying Zheng, Hemin Nie, and Jeremy J. Mao

21 Stem Cell Based Bioengineering of Craniofacial Bone 379David D. Lo, Daniel T. Montoro, Monica Grova, Jeong S. Hyun, Michael T. Chung, Derrick C. Wan, and Michael T. Longaker

22 Muscle Tissue Engineering Approaches 395Johannes W. Von den Hoff and Sander Grefte

23 Engineering of Dental Tissues: Scaffolds and Preclinical Models 409Na Yu, Adelina Plachokova, Fang Yang, X. Frank Walboomers, and John A. Jansen

24 Whole–Tooth Engineering and Cell Sources 431L. Keller, S. Kuchler–Bopp, and Herv´e Lesot

25 Bioengineering of Functional Teeth 447Takashi Tsuji

26 Pulp and Dentin Regeneration 461Misako Nakashima and George T.–J. Huang

27 Bioengineering of Roots and Periodontal Tissues 485Songlin Wang, Gang Ding, Fulan Wei, and Yi Liu

28 Periodontal Bioengineering Strategies: The Present Status and Some Developing Trends 501Fa–Ming Chen and Yan Jin

Index 525

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George T.–J. Huang, DDS, MSD, DSc, is the Director for Stem Cells and Regenerative Therapies in the College of Dentistry at the University of Tennessee Health Science Center.

Irma Thesleff, DDS, PhD, is the Research Director of the Developmental Biology Program at the Institute of Biotechnology at the University of Helsinki.

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Note: Product cover images may vary from those shown