Quality in Laboratory Hemostasis and Thrombosis. 2nd Edition
John Wiley and Sons Ltd, April 2013, Pages: 290
The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired haemorrhagic and thrombotic disorders. Its role in the monitoring of traditional anticoagulant therapy, as well as therapy using new anticoagulants, presents new challenges to the laboratory. This new edition addresses these important issues, as well as international guidelines for testing, the development of international standard materials, management of haemostasis testing from the laboratory to the point-of-care, and molecular genetic testing.
Contributors, vii
Foreword, x
Preface, xii
Steve Kitchen, John D. Olson, & F. Eric Preston
Part 1: General Quality Program
1 General quality planning in the hemostasis laboratory, 3
John D. Olson
2 Hemostasis test validation, performance, and reference intervals: international recommendations and guidelines, 12
Richard A. Marlar
3 Causes of errors in medical laboratories, 22
Giuseppe Lippi & Emmanuel J. Favaloro
4 International standards in hemostasis, 32
Trevor W. Barrowcliffe & Anthony R. Hubbard
5 Sample integrity and preanalytical variables, 45
Dorothy (Adcock) Funk
6 Internal quality control in the hemostasis laboratory, 57
Steve Kitchen, F. Eric Preston, & John D. Olson
7 External quality assessment in hemostasis: its importance and significance, 65
F. Eric Preston, Steve Kitchen, & Alok Srivastava
8 The unique challenges of hemostatic testing in children, 77
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, & Anthony K.C. Chan
Part 2: Quality in Coagulation Testing
9 Initial evaluation of hemostasis: reagent and method selection, 95
Wayne L. Chandler
10 Assay of factor VIII and other clotting factors, 105
Steve Kitchen & F. Eric Preston
11 Application of molecular genetics to the investigation of inherited bleeding disorders, 115
Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen
12 Detecting and quantifying acquired functional inhibitors in hemostasis, 124
Bert Verbruggen, Myriam Dardikh, & Britta Laros-van Gorkom
13 Standardization of d-dimer testing, 136
Guido Reber & Philippe de Moerloose
14 Point-of-care testing in hemostasis, 147
Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie
Part 3: Quality in Testing for Platelet Function and von Willebrand Disease
15 Diagnostic assessment of platelet function, 159
Paquita Nurden, Alan Nurden, & Martine Jandrot-Perrus
16 Laboratory evaluation of heparin-induced thrombocytopenia, 174
Theodore (Ted) E. Warkentin & Jane C. Moore
17 Laboratory evaluation of von Willebrand disease: phenotypic analysis, 192
Emmanuel J. Favaloro
18 Laboratory analysis of von Willebrand disease: molecular analysis, 204
Anne C. Goodeve & Ian R. Peake
Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation
19 Quality issues in heritable thrombophilia testing, 219
Isobel D. Walker & Ian Jennings
20 Evaluation of antiphospholipid antibodies, 233
Michael Greaves
21 Monitoring heparin therapy, 244
Marilyn Johnston
22 Monitoring oral anticoagulant therapy with vitamin K antagonists, 253
Armando Tripodi
23 Monitoring new anticoagulants, 264
Elaine Gray & Trevor W. Barrowcliffe
Index, 273
Steve Kitchen Royal Hallamshire Hospital, Sheffield, UK.
John D. Olson University of Texas Health Science Center, San Antonio, Texas, USA.
F. Eric Preston University of Sheffield, Sheffield, UK.
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