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Quality in Laboratory Hemostasis and Thrombosis. 2nd Edition - Product Image

Quality in Laboratory Hemostasis and Thrombosis. 2nd Edition

  • Published: April 2013
  • Region: Global
  • 290 Pages
  • John Wiley and Sons Ltd

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired haemorrhagic and thrombotic disorders. Its role in the monitoring of traditional anticoagulant therapy, as well as therapy using new anticoagulants, presents new challenges to the laboratory. This new edition addresses these important issues, as well as international guidelines for testing, the development of international standard materials, management of haemostasis testing from the laboratory to the point-of-care, and molecular genetic testing.

Contributors, vii

Foreword, x

Preface, xii

Steve Kitchen, John D. Olson, & F. Eric Preston

Part 1: General Quality Program

1 General quality planning in the hemostasis laboratory, 3
John D. Olson

2 Hemostasis test validation, performance, and reference intervals: international recommendations and guidelines, 12
Richard A. Marlar

3 Causes of errors in medical laboratories, 22
Giuseppe Lippi & Emmanuel J. Favaloro

4 International standards in hemostasis, 32
Trevor W. Barrowcliffe & Anthony R. Hubbard

5 Sample integrity and preanalytical variables, 45
Dorothy (Adcock) Funk

6 Internal quality control in the hemostasis laboratory, 57
Steve Kitchen, F. Eric Preston, & John D. Olson

7 External quality assessment in hemostasis: its importance and significance, 65
F. Eric Preston, Steve Kitchen, & Alok Srivastava

8 The unique challenges of hemostatic testing in children, 77
M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, & Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial evaluation of hemostasis: reagent and method selection, 95
Wayne L. Chandler

10 Assay of factor VIII and other clotting factors, 105
Steve Kitchen & F. Eric Preston

11 Application of molecular genetics to the investigation of inherited bleeding disorders, 115
Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen

12 Detecting and quantifying acquired functional inhibitors in hemostasis, 124
Bert Verbruggen, Myriam Dardikh, & Britta Laros-van Gorkom

13 Standardization of d-dimer testing, 136
Guido Reber & Philippe de Moerloose

14 Point-of-care testing in hemostasis, 147
Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie

Part 3: Quality in Testing for Platelet Function and von Willebrand Disease

15 Diagnostic assessment of platelet function, 159
Paquita Nurden, Alan Nurden, & Martine Jandrot-Perrus

16 Laboratory evaluation of heparin-induced thrombocytopenia, 174
Theodore (Ted) E. Warkentin & Jane C. Moore

17 Laboratory evaluation of von Willebrand disease: phenotypic analysis, 192
Emmanuel J. Favaloro

18 Laboratory analysis of von Willebrand disease: molecular analysis, 204
Anne C. Goodeve & Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation

19 Quality issues in heritable thrombophilia testing, 219
Isobel D. Walker & Ian Jennings

20 Evaluation of antiphospholipid antibodies, 233
Michael Greaves

21 Monitoring heparin therapy, 244
Marilyn Johnston

22 Monitoring oral anticoagulant therapy with vitamin K antagonists, 253
Armando Tripodi

23 Monitoring new anticoagulants, 264
Elaine Gray & Trevor W. Barrowcliffe

Index, 273

Steve Kitchen Royal Hallamshire Hospital, Sheffield, UK.

John D. Olson University of Texas Health Science Center, San Antonio, Texas, USA.

F. Eric Preston University of Sheffield, Sheffield, UK.

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