Edited by
Hussain I Saba MD, PhD
Professor of Medicine
Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center
USF College of Medicine
Professor Emeritus
Department of Malignant Hematology
Moffitt Cancer Center and Research Institute
Tampa, FL, USA
Harold R Roberts MD
Emeritus Professor of Medicine and Pathology
Division of Hematology / Oncology
University of North Carolina
Chapel Hill, NC, USA
Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients.
Hemostasis and Thrombosis: Practical Guidelines in Clinical Managementcovers all aspects of the practical
management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day-to-day management. The most clinically relevant material from the literature has been carefully compiled, along with:
- Discussions of new and upcoming diagnostic and therapeutic modalities
- Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis
Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, Hemostasis and Thrombosis: Practical Guidelines in Clinical Management will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis.
Table of Contents
Contributors, vii
Preface, x
Acknowledgments, xi
1 Theories of Blood Coagulation: Basic Concepts and Recent Updates, 1
Dougald M. Monroe and Maureane Hoffman
2 Vascular Endothelium, Infl uence on Hemostasis: Past and Present, 14
Hussain I. Saba and Sabiha R. Saba
3 Coagulation Testing: Basic and Advanced Clinical Laboratory Tests, 30
Nils Egberg and Margareta Blombäck
4 Factor VIII Defi ciency or Hemophilia A: Clinical Bleeding and Management, 45
Pier Mannuccio Mannucci and Massimo Franchini
5 Factor IX Defi ciency or Hemophilia B: Clinical Manifestations and Management, 57
Raj S. Kasthuri, Harold R. Roberts, and Paul E. Monahan
6 Factor XI Deficiency or Hemophilia C, 71
Charles E. Bane, Anne T. Neff, and David Gailani
7 Factor VIII and IX Inhibitors in Hemophilia, 82
Meera Chitlur and Jeanne Lusher
8 Treatment Options for Acquired Hemophilia, 93
Anjali Sharathkumar and David Green
9 Factor XII Deficiency or Hageman Factor Deficiency, 112
Evi X. Stavrou and Alvin H. Schmaier
10 Inherited Combined Factor Deficiency States, 127
Asma Latif and Louis Aledort
11 Acute and Chronic Immune Thrombocytopenia: Biology, Diagnosis, and Management, 137
Samir Dalia and Benjamin Djulbegovic
12 Disseminated Intravascular Coagulation: Diagnosis and Management, 151
Stephanie J. Davis and Craig M. Kessler
13 Mechanisms of Fibrinolysis and Basic Principles of Management, 169
John W. Weisel and Rustem I. Litvinov
14 Post-thrombotic Syndrome, 186
Jean-Philippe Galanaud and Susan R. Kahn
15 Von Willebrand Disease: Clinical Aspects and Practical Management, 197
Francesco Rodeghiero, Alberto Tosetto, and Giancarlo Castaman
16 Platelets in Hemostasis: Inherited and Acquired Qualitative Disorders, 209
Noman Ashraf and Hussain I. Saba
17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis, 236
James H. Morrissey
18 Thrombotic Microangiopathy: Biology, Diagnosis, and Management, 246
Samir Dalia and Hussain I. Saba
19 Hemostasis and Aging, 259
Lodovico Balducci
20 Hemostatic Problems in Chronic and Acute Liver Disease, 271
Ton Lisman and Robert J. Porte
21 Cancer and Thrombosis, 284
Erica A. Peterson and Agnes Y. Y. Lee
22 An Update on Low-Molecular-Weight Heparins, 296
Jawed Fareed, Debra Hoppensteadt, and Walter P. Jeske
Index, 315
Color plate section can be found facing page 212
