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Electrospinning for Tissue Regeneration. Woodhead Publishing Series in Biomaterials

  • ID: 2719575
  • June 2011
  • 424 Pages
  • Elsevier Science and Technology
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Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector.

The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research.

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Part I: Fundamentals of electrospinning

Chapter 1: Introduction to electrospinning

Abstract:

1.1 Introduction

1.2 Basic concepts

1.3 Morphology and structural formation

1.4 Parameters

1.5 Apparatus

1.6 Materials

1.7 Applications

1.8 Future trends

Chapter 2: Polymer chemistry

Abstract:

2.1 Introduction

2.2 Natural polymers

2.3 Synthetic degradable polymers

2.4 Conclusions

Chapter 3: The electrospinning process, conditions and control

Abstract:

3.1 Introduction

3.2 Solution parameters

3.3 Processing parameters

3.4 Ambient parameters

3.5 Conclusions

Chapter 4: Regulatory issues relating to electrospinning

Abstract:

4.1 Introduction

4.2 Regulation of materials in regenerative medicine

4.3 Future trends

4.4 Sources of further information and advice

Part II: Electrospinning for tissue regeneration

Chapter 5: Bone tissue regeneration

Abstract:

5.1 Introduction

5.2 Principles of bone biology

5.3 Strategies for bone regeneration

5.4 Fabrication of scaffolds for bone tissue engineering

5.5 Potential materials for scaffolds

5.6 Osteoporosis: a growing problem

5.7 Strategies for the treatment of bone defects

5.8 Conclusions and future trends

Chapter 6: Cartilage tissue regeneration

Abstract:

6.1 Introduction

6.2 Culture of chondrogenic cells for implantation

6.3 Electrospun nanofibre scaffolds

6.4 Future trends

Chapter 7: Muscle tissue regeneration

Abstract:

7.1 Introduction to skeletal muscle

7.2 Skeletal muscle injuries

7.3 Mechanical properties of skeletal muscle

7.4 Tissue engineering

7.5 Contractile force

7.6 Conductive elements

7.7 Conclusion and future trends

Chapter 8: Tendon tissue regeneration

Abstract:

8.1 Introduction: tendon tissue

8.2 Tendon structure and composition

8.3 Tendon pathology

8.4 Clinical need

8.5 Tissue engineering

8.6 Cell response to electrospun bundles

8.7 Mechanical properties of electrospun bundles

8.8 Conclusions and future trends

8.9 Acknowledgements

Chapter 9: Nerve tissue regeneration

Abstract:

9.1 Introduction

9.2 Clinical problems in nerve tissue therapy

9.3 Nerve tissue engineering

9.4 Biomimetic nanoscaffolds for peripheral nerve regeneration

9.5 Stem cell therapy with nanofibre for nerve regeneration

9.6 Conclusion and perspectives

Chapter 10: Heart valve tissue regeneration

Abstract:

10.1 Introduction

10.2 Tissue to be replaced: heart valves

10.3 Specific tissue requirements as a blueprint for scaffold properties

10.4 Selection of scaffold material

10.5 Scaffold properties to meet tissue requirements

10.6 Future trends

10.7 Acknowledgment

Chapter 11: Bladder tissue regeneration

Abstract:

11.1 Structural/functional properties of the bladder

11.2 Bladder disease and the need for bladder substitution

11.3 Electrospun and other scaffolds for bladder tissue engineering

11.4 Electrospinning fit for purpose

11.5 Future trends

11.6 Conclusions

11.7 Acknowledgement

Chapter 12: Tracheal tissue regeneration

Abstract:

12.1 Anatomy of the trachea and main pathologies of surgical concern

12.2 Tissue engineered trachea (TET)

12.3 Electrospun biodegradable tubular tracheal scaffold

12.4 Scaffold fulfilment

12.5 In vitro and in vivo evaluation of the cell and tissue response

12.6 Conclusions

12.7 Acknowledgements

Chapter 13: Dental regeneration

Abstract:

13.1 Introduction

13.2 Periodontal regeneration

13.3 Reinforcement of dental restorations

13.4 Conclusions and future trends

Chapter 14: Skin tissue regeneration

Abstract:

14.1 Introduction

14.2 Biology of skin and wound healing

14.3 Challenging problems in existing therapies

14.4 Restoring functional skin tissue

14.5 Nanofibres as extracellular matrix analogue

14.6 Ideal properties of scaffold

14.7 Choice of biomaterial

14.8 Cellular interactions on skin substitute

14.9 Conclusions and future trends

Chapter 15: Wound dressings

Abstract:

15.1 Introduction: wound healing

15.2 Nanofibres

15.3 Antimicrobial nanofibrous wound dressings

15.4 Conclusions

Part III: Electrospinning for in vitro applications

Chapter 16: Cell culture systems for kidney research

Abstract:

16.1 Introduction

16.2 Current work

16.3 Electrospun materials

16.4 Scanning electron microscopy of cells on electrospun scaffolds

16.5 Immunostaining of extracellular matrix proteins on electrospun scaffolds

16.6 Immunostaining of cells on electrospun scaffolds

16.7 Comparison of culture methods

16.8 Discussion and future trends

16.9 Acknowledgements

Chapter 17: Cell culture systems for pancreatic research

Abstract:

17.1 Introduction

17.2 Min6 cell line

17.3 Nes2y cells

17.4 Novel scaffolds and production methods

17.5 Methods

17.6 Results

17.7 Discussion

17.8 Future trends

17.9 Conclusion

Chapter 18: Cell culture systems for stem cell research

Abstract:

18.1 Introduction

18.2 Embryonic stem cells

18.3 Current culture techniques

18.4 3D scaffolds

18.5 Combining ES cells with electrospun scaffolds

18.6 Future trends

Index

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Bosworth, L
Dr. Lucy A. Bosworth and Professor Sandra Downes both work in the Materials Science Centre at The University of Manchester, UK and are widely renowned for their research into biomaterials, tissue engineering and electrospinning.
Downes, S

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