Diabetes and the Nervous System. Handbook of Clinical Neurology Volume 126

Table of Contents

Section 1. CLINICAL IMPACT OF DIABETES ON THE NERVOUS SYSTEM 1. Epidemiology of polyneuropathy in diabetes and prediabetes 2. Clinical features of diabetic polyneuropathy 3. Focal and entrapment neuropathies 4. Diabetic radiculoplexus neuropathies 5. Painful diabetic neuropathy: clinical aspects 6. Diabetic autonomic neuropathy 7. Motor neuropathy 8. Diabetic neuropathy and foot ulceration 9. Glucose intolerance and neuropathy 10. Diabetic neuropathy in children 11. Cognitive disorders in diabetic patients 12. Stroke and diabetes mellitus 13. Neurological infections in diabetes mellitus 14. Recognition and management of psychosocial issues in diabetic neuropathy 15. Overview of diabetes management in patients with neurological disorders 16. Sexual dysfunction in diabetes

Section 2. DIAGNOSTIC AND THERAPEUTIC APPROACHES TO DIABETIC NEUROLOGICAL COMPLICATIONS 17. Electrophysiological testing in diabetic neuropathy 18. Diabetic neuropathy and nerve structure 19. Epidermal innervation in diabetes 20. Clinical and diagnostic features of small fibre damage in diabetic polyneuropathy 21. CNS imaging in cerebrovascular and white matter disease 22. Therapy for diabetic neuropathy: an overview 23. Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy

Section 3. FUNDAMENTAL STUDIES OF DIABETIC NEUROSCIENCE 24. Neuroscience of glucose homeostasis 25. Mechanisms of disease 1. Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes 26. Mechanisms of diabetic neuron damage: molecular pathways 27. Mechanisms of diabetic neuropathy 3: Schwann cells 28. Mechanisms of disease: axon dysfunction 29. Mechanisms of disease: role of neurotrophins in diabetes and diabetic neuropathy 30. Experimental motor neuropathy in diabetes 31. Ischemic neuropathy 32. Diabetes and neurodegeneration in the brain 33. Neurological damage in hypoglycemia 34. Painful neuropathy-mechanisms 35. Insights into the pathogenesis and treatment of painful diabetic neuropathy 36. Autonomic neuropathy in experimental models of diabetes mellitus

Authors

Douglas W. Zochodne Division of Neurology, Department of Medicine and the Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada. Dr. Douglas Zochodne is a Neurologist and Neuroscientist, Divisional Director of Neurology at the University of Alberta (UofA) and Director of the Neuroscience and Mental Health Institute, UofA. He was trained in Neurology and Neuromuscular Diseases the University of Western Ontario (now Western University) and at Mayo Clinic. Dr. Zochodne's career has included faculty positions at Queen's University, Canada, the University of Calgary and more recently the University of Alberta. He has devoted his career toward understanding the biology and diseases of the peripheral nervous system. Dr. Zochodne's roles have included Editor-in-Chief of the Canadian Journal of Neurological Sciences (1999-2007), President of the Peripheral Nerve Society (2009-2011). He is a Fellow of the Canadian Academy of Health Sciences and was awarded the Wolfe Prize in Neuropathy research by the American Neurological Association in 2011 and the Alan J. Gebhart Prize for Excellence in Peripheral Nerve Research, Peripheral Nerve Society in 2019. Dr. Zochodne has channeled his research as an investigator of diabetic polyneuropathy and peripheral neuron regeneration. His laboratory has been funded continuously since 1988 and it has published over 285 research papers and chapters including four books. Rayaz A. Malik Centre for Endocrinology & Diabetes, Institute of Human Development, University of Manchester, Manchester, UK. Rayaz A. Malik is a Professor of Medicine at Weill Cornell Medical College, Qatar and Honorary Professor of Medicine and Consultant Physician in the Centre for Endocrinology and Diabetes, Central Manchester University Teaching Hospitals Foundation Trust and University of Manchester. He obtained his BSc., MSc. and MB ChB from the University of Aberdeen and his PhD from the University of Manchester. He is an expert in the pathogenesis, assessment and treatment of diabetic neuropathy and has been a co-editor for three books, co-authored over 30 book chapters and published (~130 peer reviewed papers) and presented (~500 national and international presentations) extensively. His research is funded by the NIH, JDRF, DUK, BHF and EU and his funding totals ~$8M. He was the Chairman of Neurodiab, the international study group of the EASD for Diabetic Neuropathy (2009-2012). He won the young clinical investigator prize for clinical science for Neurodiab in 1999, North West of England Medical Society Prize in 2000; North East Medical Society Prize 2012. He has been an invited lecturer for the American Diabetes Association 2003, 2007 and 2010, 2012, 2013; European Association for the Study of Diabetes 2004, 2007, 2008, 2010, 2012 and 2013 and World Diabetes Congress 2009, 2011, 2013. He is an associate editor for Diabetic Medicine (2006 to present); BMC Neurology (2009-present); Advances in Therapy (2009-present) and is on the editorial board for Journal of Diabetes and Its Complications (2012-present) and Journal of Diabetes Investigation (2012-present).