Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
Table of Contents
1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects? 2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army 3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where's the baby? 4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle 5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure 6. Assembly and disassembly of protein aggregates: Unraveling the maze
