Synthetic Biology, A New Paradigm For Biological Discovery - Market Research Reports

Contents:

1 Introduction.
1.1 Scope of Report
1.2 Overview of Synthetic Biology
1.2.1 Definition of Synthetic Biology
1.2.2 Overview of Current Application Areas
1.2.3 Basics of Synthetic Biology
1.2.4 Why is Synthetic Biology Important?
1.2.5 Synthetic Biology's Role in Genetics

2 Oligonucleotides/DNA
2.1 Synthetic Oligonucleotide/DNA-based Technologies
2.1.1 Expanded Bases
2.1.2 Nanocircles
2.1.3 Recombinant DNA (rDNA)
2.1.4 Aptamers
2.2 Applications of Synthetic DNA
2.2.1 Expanded Bases used in Assays
2.2.2 Nanocircles
2.2.3 Examples of Recombinant DNA Products
2.2.4 Aptamers
2.2.5 Expert Opinion on Market Potential

3 RNA
3.1 Synthetic RNA-based Technologies
3.1.1 RNA Interference (RNAi)
3.1.2 Antisense Technology
3.1.3 Riboswitches
3.1.4 Riboregulators
3.1.5 Riboswitch/Riboregulator Hybrids
3.2 Applications of Synthetic Biology in RNA
3.2.1 RNAi Therapeutics
3.2.2 Antisense Technology

4 Peptides-based Molecules
4.1 Synthetic Peptide-based Technologies
4.1.1 Synthetic Antibodies
4.1.2 Engineered Kinases
4.2 Applications of Synthetic Peptides and Proteins
4.2.1 Synthetic Antibodies
4.2.2 Kinases
4.2.3 Novel Delivery Systems
4.2.4 Tapet®: Tumor Amplified Protein Expression Therapy
4.2.5 Hematide (Affymax)
4.2.6 Genetically Engineered Recombinant Protein Vaccines: Present and
Future Applications

5 Metabolites
5.1 Synthetic Polyketide Technologies
5.2 Applications of Synthetic Polyketides

6 Organisms
6.1 Technologies of Directed Evolution and Microbial Engineering
6.2 Applications of Directed Evolution and Microbial Engineering
6.2.1 Diversa's DirectEvolution™
6.2.2 Microbial Engineering
6.2.3 Future Application of Microbial Engineering: crHIV-1
6.2.4 Bioremediation.
6.3 Technology of Biosensing Cells
6.4 Applications of Biosensing Cells
6.4.1 BioFlash™
6.4.2 Biosensors that Measure Cell Division

7 Environmental Research
7.1 Energy Research
7.1.1 The Institute for Biological Energy Alternatives (IBEA)

8 Synthetic Biology Informatics

9 Potential Hazards of Synthetic Biology

10 Synthetic Biology Market Overview
10.1 Synthetic Biology Partnerships
10.2 Commercial Opportunities and Outlook
10.3 Synthetic Biology Market Projections
10.3.1 Synthetic Biology Pharmaceutical Market Analysis
10.3.2 Life Science Reagents Market
10.4 Open Source

11 Selected Synthetic Biology Thought-leader Profiles

12 Expert Interviews

13 Synthetic Biology Companies

List of Figures
Figure 1-1. Taxonomy of Synthetic Biology Technologies with Current and Future
Applications*
Figure 1-2. The process of DNA to RNA to proteins
Figure 2-1. Chemical Structure Comparison of DNA and xDNA
Figure 2-2. Synthesis of xA and xT
Figure 2-3. Examples of Published Knock-down Studies using Aptamers In Vitro or
in Animals
Figure 2-4. DNA-streptavidin Nanocircles
Figure 3-1. Initiation and Elongation Steps in the Process of Translation
Figure 3-2. Mechanism of RNAi
Figure 3-3. The Production of Faulty Proteins and the Inhibition of this Production by
Antisense
Figure 3-4. Riboswitch-mediated Gene Regulation
Figure 3-5. Design and Functional Activity of an Antiswitch Regulator
Figure 3-6. Engineered RNA Switch System
Figure 3-7. Isis Pharmaceuticals' Proprietary Drug Discovery Process
Figure 4-1. Cell Death Caused by Anthrax Toxin
Figure 4-2. Mechanism of Action of ABthrax™
Figure 4-3. Express-si Delivery Technology
Figure 4-4. Percentage of Patients with Hemagglutination Inhibition (HAI) Treated
with FluBlock at 15, 40, and 160 µg in Comparison with FluZone 15 µg
Figure 5-1. Examples of Polyketides
Figure 5-2. "Lego-zation" Principle for the Assembly of New Polyketide Synthases
Figure 5-3. The Process of Chemo-biosynthesis Technology used by Kosan
Biosciences
Figure 5-4. Heterologous Over-expression for Increased Production of Polyketides
Figure 6-1. An Idealized Biorefinery Concept
Figure 6-2. E. coli Bacteria Programmed to Form a Bull's Eye Pattern
Figure 10-1. Synthetic Biology Impact on the Human Healthcare Paradigm
Figure 10-2. 10-year Antibody Market Projection
Figure 10-3. 10-year Synthetic Reagents Market Projection
Figure 10-4. Registry Parts Index

List of Tables
Table 2-1. Comparison of Aptamer and Antibody Properties
Table 3-1. Companies involved in RNAi Technology
Table 3-2. Various Companies involved in Antisense Technology
Table 4-1. Biotechnology Companies involved in Synthetic Antibody Production
Table 4-2. Product Development Summary of Kinases by Therapeutic Area currently
being Investigated
Table 6-1. Various Companies involved in Directed Evolution Technologies
Table 10-1. Examples of Selected Partnerships of Academic Institutions,
Biotechnology Companies and Pharmaceutical Companies
Table 10-2. Time to Market Analysis of Synthetic Biology Therapeutic Products
Table 10-3. Ribosome Binding Sites
Table 11-1. Selected Thought-leaders in the Field of Synthetic Biology
Table 13-1. Biotechnology or Pharmaceutical Companies with an Interest in Synthetic
Biology

Summary:

This report defines the overall field of synthetic biology and provides a definition of synthetic biology based on the interpretations of engineers, chemists and biologists who specialize in this field. Although there are several variations on the definition of synthetic biology, there are commonalities which hold throughout and are discussed. Ongoing research from academic institutions as well as biotechnology and pharmaceutical companies are discussed at length. Discoveries and applications from the field of synthetic biology, both current and future, are detailed, and business opportunities from these applications are investigated. Biotechnology and pharmaceutical companies as well as academicians involved in synthetic biological research are mentioned, along with partnerships formed between the different industries. As much of the research begins in the laboratories of the academic institutions and then branches out to the companies that can advance and market it, this report begins with a discussion of the definition of synthetic biology.