Overview
At present, the pharmaceutical industry is dominated by the presence of small molecule products, which represent close to 80% of the overall pipeline. Even though biologics have shown significant promise in the treatment of a wide range of disorders, in recent years, approval of novel small molecules has been on the rise. In fact, in 2020, over 50 small molecule drugs were approved by the US FDA, while around 8,000 such candidates are being evaluated across different stages of development. It is worth mentioning that the pipeline features increasingly complex candidates, which require specialized facilities, advanced equipment and operational expertise. As setting-up/acquiring manufacturing capabilities is both time and cost intensive process, it is extremely challenging for pharmaceutical companies to perform development and manufacturing operations independently. The aforementioned constraints, coupled to the rising demand for safer and effective drugs (currently driven by the COVID-19 pandemic), have prompted players to outsource a significant portion of their business segments to contract manufacturing organizations (CMOs), and contract development and manufacturing organizations (CDMOs).
The current landscape of pharmaceutical contract service providers is highly fragmented, featuring a mix of start-ups, mid-sized firms and established players. The inherent expertise of CMOs and CDMOs is believed to be capable of enabling reduction in the time-to-market a product, significant cost-benefits, as well as access to larger production capacities and novel technologies. It is worth mentioning that there has been substantial merger and acquisition activity in the pharmaceutical contract manufacturing market in the past few years, as players strive to become one stop shops, in order to cater to the diverse needs of pharmaceutical developers (ranging from early-stage development to commercial production). Considering the ongoing innovation in production technologies, evolving pipeline of small molecule products and the increasing demand for such drug candidates, we believe that the pharmaceutical contract manufacturing market is likely to witness positive growth in the coming years.
Scope of the Report
The “Pharmaceutical Contract Manufacturing Market (3rd Edition) Distribution by key business segments (API(s) and FDF(s)), type of API(s) manufactured (branded and generic), type of FDF(s) offered (oral solids, parenteral and others), type of primary packaging form (blisters, bottles, injectables and others), scale of operation (clinical and commercial), type of end-users (small pharmaceutical companies, mid-sized pharmaceutical companies and large pharmaceutical companies) and key geographical regions (North America, Europe, Asia-Pacific, Latin America, and Middle East and North Africa: Industry Trends and Global Forecasts, 2021-2030” report features an extensive study of the current market landscape and future opportunities associated with the pharmaceutical contract manufacturing industry.
Amongst the other elements, the report features:
- A detailed overview of the overall market landscape, featuring an elaborate list of over 450 active CMOs engaged in this domain, along with information on several relevant parameters, such as year of establishment, company size, geographical location of CMOs, type of business segment (active pharmaceutical ingredients (APIs), intermediates and finished dosage formulations (FDFs)), type of API(s) manufactured (complex, generic and sterile), type of FDF(s) offered (oral solids, liquids/semi-solids, injectables, inhalation and others), type of service(s) offered, type of primary packaging form (blister, tubes, vial/cartridge, ampoule, sachets/pouches/bags, inhalers/nasal sprays, glass/plastic/dropper bottles, pre-filled syringes/autoinjectors), scale of operation (preclinical, clinical and commercial) and specific location of manufacturing facilities (country-wise).
- A detailed analysis of various mergers and acquisitions that have taken place in this domain, highlighting the trend in number of companies acquired and geographical distribution of the activity, during the period 2017-2021. Further, it highlights the relationship between deal multiples (based on revenues), number of employees and experience of the acquired firm.
- A detailed analysis of the recent expansions (since 2017) undertaken by various service providers in order to augment their respective pharmaceutical contract manufacturing service portfolios, based on a several relevant parameters, such as year of expansion, purpose of expansion (capability expansion, capacity expansion, facility expansion, new facility), type of business segment (API(s), FDF(s)), capital invested, scale of operation (clinical, commercial), type of service(s) offered (formulation, manufacturing, packaging), geographical location of facility, and most active players (in terms of number of instances).
- An estimate of the global, installed capacity for the manufacturing of small-molecule drugs, based on information provided by various industry stakeholders in the public domain. It also features distribution of the available capacity on the basis of scale of operation (clinical and commercial), company size (small, mid-sized and large firms) and key geographical regions (North America, Europe and Asia Pacific).
- Informed estimates of the annual clinical and commercial demand for small molecule drugs, across key geographical regions.
- A detailed analysis of pharmaceutical contract manufacturing service providers’ capabilities in different regions, based on several relevant parameters, such as type of business segment, type of service(s) offered and type of packaging form.
- A detailed analysis of various pharmaceutical contract manufacturing service providers featuring schematic representations, including [A] a heat map analysis, highlighting the distribution of integrated contract service providers (companies offering manufacturing services for both small and large molecules), on the basis of location of their headquarters, year of establishment and number of employees, [B] a geographical landscape analysis, highlighting CMOs that have a wide geographical reach, on the basis of their presence (manufacturing facilities) across various regions, and [C] a grid representation, highlighting the global and regional trend of API and FDF outsourcing services, based on the location of headquarters of the company, number of employees, type of business segment, type of service(s) offered and scale of operation.
- A detailed discussion on various guidelines laid down by major regulatory bodies, across different countries, featuring an elaborative assessment of over 450 CMOs engaged in this domain, along with information on their operational approvals, certifications received, and relative popularity of the key regulatory body. Additionally, the chapter features an insightful multi-dimensional bubble analysis, presenting a comparison of the current regulatory scenario in key geographies.
- Elaborate profiles of key players engaged in offering pharmaceutical contract manufacturing services. Each profile features a brief overview of the company, along with information on its financial performance (if available), service(s) portfolio, manufacturing facilities and capabilities, recent developments and an informed future outlook.
- A case study highlighting a comparison of the key characteristics of large and small molecule drugs, along with information on the steps involved in their respective manufacturing processes.
- A qualitative analysis highlighting the various factors that need to be taken into consideration by pharmaceutical drug developers, while deciding whether to manufacture their respective products in-house or engage the services of a CMO.
- A detailed analysis capturing the key parameters and trends that are likely to influence the future of the pharmaceutical contract manufacturing market, under an elaborate SWOT framework. Further, it presents a schematic Harvey ball analysis highlighting the relative impact of each SWOT parameter on the overall pharmaceutical industry.
One of the key objectives of the report was to understand the primary growth drivers and estimate the future opportunity within the market based on several parameters, such as growth of the overall pharmaceutical market, cost of goods sold, direct manufacturing costs. We have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2021-2030. The report also features the likely distribution of the opportunity across [A] key business segments (API(s) and FDF(s)), [B] type of API(s) manufactured (branded and generic), [C] type of FDF(s) offered (oral solids, parenteral and others), [D] type of primary packaging form (blisters, bottles, injectables and others), [E] scale of operation (clinical and commercial), [F] type of end-users (small pharmaceutical companies, mid-sized pharmaceutical companies and large pharmaceutical companies) and [G] key geographical regions (North America, Europe, Asia-Pacific, Latin America, and Middle East and North Africa. In order to account for future uncertainties and add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders in this domain.
The report features detailed transcripts of interviews held with the following individuals:
- Scott Goldstein (Ex - Director, Business Development, Ajinomoto Bio-Pharma Services)
- Thomas Früh (Ex - CEO, Bachem)
- Bhaskar Venepalli (President and CEO, CiVentiChem)
- Roberto Margarita (Director, Business Development, CordenPharma)
- Allison Vavala (Director, Commercial Development, Helsinn Group)
- Kevin Daley (Director, Pharmaceuticals Marketing, Novasep)
- Piyush Desai (Director, Operations, Sovereign Pharma)
- Ilan Avni (Vice President Business Development, Marketing, and IP, Wavelength Pharmaceuticals)
All actual figures have been sourced and analyzed from publicly available information forums. Financial figures mentioned in this report are in USD, unless otherwise specified.
Key Questions Answered
- Who are the key players engaged in offering contract manufacturing services for small molecules?
- What are the key value drivers of the merger and acquisition activity observed within the pharmaceutical contract manufacturing industry?
- What are the different expansion initiatives undertaken by pharmaceutical contract manufacturers in the recent past?
- Which regions represent the current key contract manufacturing hubs for small molecules? What is the current, installed capacity for contract manufacturing of small molecules?
- What is the current, global demand for small molecules? How is the demand for such candidates likely to evolve in the foreseen future?
- What percentage of the pharmaceutical manufacturing operations are presently outsourced?
- What factors should be taken into consideration while deciding whether the manufacturing operations for small molecules should be kept in-house or outsourced?
- How is the current and future opportunity likely to be distributed across key market segments?
Please note: This report can be updated on request. Please contact our Customer Experience team using the Ask a Question widget on our website.
Table of Contents
Companies Mentioned
- A. S. Joshi & Company
- Aarti Industries
- AbbVie
- Abiogen Pharma
- Accra Pac
- ACIC Pharmaceuticals
- Acino
- Acme Group
- Acorda Therapeutics
- ACS Dobfar
- Actiza Pharmaceutical
- Adare Pharmaceuticals
- Admac Formulations
- Advent International
- Aenova
- Afton Scientific
- AGIC Capital
- Agno Pharma
- Aiomedic Pharmaceuticals
- AiPing Pharmaceutical
- Ajinomoto Bio-Pharma Services
- Akorn
- Akrikhin
- Akums Drugs & Pharmaceuticals
- Albatross Pharmaceuticals
- Albemarle
- AlbyPharma
- Alcami
- Alembic Pharmaceuticals
- Alkem Laboratories
- Alkermes
- Allchem Laboratories
- Almac
- Almelo
- Alps Pharmaceutical
- Altasciences
- Althea Pharma
- Alvogen
- Amanta Healthcare
- AmbioPharm
- American Regent
- Ami Lifesciences
- Amman Pharmaceutical Industries
- Amneal Pharmaceuticals
- Amoli Organics
- AMPAC Fine Chemicals
- AMRI
- Angelini Pharma
- Anhui Biochem United Pharmaceutical
- ANI Pharmaceuticals
- Ankur Drugs and Pharma
- Anqiu Lu'an Pharmaceutical
- Anugraha Chemicals
- ANVI Pharma
- API Co. Ltd
- API Pharma Tech
- Apicore
- Apiscent Laboratories (acquired by Kingchem Life Sciences)
- APL Pharma Specials
- Appco Pharma
- Aptuit
- Arbro Pharmaceuticals
- Arch Pharmalabs
- Arcinova
- Ardena
- Arevipharma
- Argonaut
- Aristo Pharma
- Arvincare
- Aspen
- Aspen Pharmacare
- Aster Pharma
- Asymchem
- Atra Pharmaceuticals
- Aurigene Pharmaceutical Services
- Aurobindo Pharma
- Austar Pharma
- Avara Pharmaceutical Services
- Avra Laboratories
- AVVA Pharmaceuticals
- Axa Parenterals
- Baccinex
- Bachem
- Bal Pharma
- Bankyo Pharmaceutical
- Batterjee Pharma
- Bausch Health
- Baxter
- Baxter BioPharma Solutions
- BCN Peptides
- BDR Pharmaceuticals
- Belco Pharma
- Bellwyck Pharma Services (acquired by PCI Pharma Services)
- Beltapharm
- Bennet Pharmaceuticals
- BePharBel
- Beximco Pharmaceuticals
- BINEX
- Biological E
- Biophore
- Bioserv
- Biosint
- Bio-Synthesis
- BioVectra
- Biozoc
- Bluepharma
- Bonarum Pharma
- Bora Pharmaceuticals
- Brassica Pharma
- Bridgepoint
- Bristol Laboratories
- Broad Pharmaceutical
- Bushu Pharma
- Cadila Pharmaceuticals
- Calyx Chemicals & Pharmaceuticals
- Cambrex
- Canonpharma
- Caplin Point Laboratories
- Capsugel
- CARBOGEN AMCIS
- Carlyle Group
- Cascade Chemistry
- Catalent
- Cayman Chemical
- Cenexi
- Centaur Pharmaceuticals
- Century Pharmaceuticals
- Cerbios-Pharma
- Chartwell Pharmaceuticals
- ChemCon
- ChemConnection
- Chemigran
- ChemPacific
- Chiral Biosciences
- Chirogate International
- Chongqing Huapont Pharmaceutical
- Chromo Laboratories
- Chunghwa Chemical Synthesis & Biotech
- Ciron Drugs
- CiVentiChem
- CJ HealthCare
- Claris Injectables (acquired by Baxter)
- Clearsynth
- CMIC Group
- Coating Place
- Concord Drugs
- Confab Laboratories
- Consort Medical
- Contract Coating
- Contract Pharmacal
- Copperhead Chemical Company
- CordenPharma
- CoreRx
- CPC Scientific
- Contract Pharmaceuticals Limited (CPL)
- Crenza Pharmaceuticals
- Cris Pharma
- Crown Laboratories
- CTX Lifesciences
- Daiichi Sankyo
- Daito Pharmaceutical
- Dalton Pharma Services
- DBK Pharmaceutical
- Dearborn Partners
- Dechra Pharmaceuticals
- Delmar Chemicals
- Delpharm
- Delta Laboratories
- Dermopartners
- DEVA
- Dhanuka Labortories
- Dhruv Life Sciences
- Dipharma
- Dishman Biotech (acquired by CARBOGEN AMCIS)
- DIVERCHIM
- Divi's Laboratories
- DM Pharma Marketing
- Dottikon Exclusive Synthesis
- Douglas Pharmaceuticals
- DPT Laboratories
- Dr. Pradeep Reddy's Laboratories
- Dupen Laboratories
- Dwarkesh Pharmaceuticals
- EirGen Pharma
- E.L. Laboratories
- Elfin
- Elite Pharmaceuticals
- Embio
- Emcure Pharmaceuticals
- Emergent BioSolutions
- Eminent Healthcare
- Enaltec
- Entema Laboratories
- Entod Pharmaceuticals
- Epic Pharma
- Ercros
- Eriochem
- Erregierre
- Esteve
- Ethypharm
- Eurofins
- Euro-Med Laboratories
- EVER Pharma
- Evonik Industries
- Evotec
- Exela Pharma Sciences
- FAMAR
- Fareva
- Farmak
- Farmasierra
- Farmhispania Group
- Farmigea
- Fermion
- Ferndale laboratories
- FineTech Pharmaceuticals
- Flamingo Pharmaceuticals
- Flamma
- Fleming Laboratories
- Fresenius Kabi
- FTF Pharma
- Fuji Chemical
- Fuji Pharma
- Fujifilm RI Pharma
- Fujimoto Chemicals
- Future Pak
- Galentic Pharma
- G.D Pharmaceuticals
- Gebro Pharma
- Gedeon Richter
- General Atlantic
- Getz Pharma
- GHO Capital
- Gland Pharma
- Glatt
- GlaxoSmithKline
- Glenmark Pharmaceuticals
- Globela Pharma
- Glochem Industries
- GP Pharm
- Grand River Aseptic Manufacturing
- Granules India
- Grindeks
- Groupe PARIMA
- Grünenthal
- Guardian Drug Company
- GVK BIO
- Halo Pharma
- Handok
- Hanford Pharmaceuticals
- Hangzhou Hysen Pharma
- Hanuchem Laboratories
- HBM Pharma
- Health Biotech
- Healthy Life Pharma
- Helios Pharmaceuticals
- Helsinn Group
- Hetero Drugs
- H.I.G Capital
- Hikal
- Hovione
- HP Toride Pharma
- Hritik Chemicals
- Hubei Biocause Pharmaceutical
- Huvepharma
- ICROM
- IDT Australia
- Impopharma (acquired by Rubicon Research)
- Indena
- Indoco Remedies
- Ind-Swift Laboratories
- Ingenus Pharmaceuticals
- Innova Captab
- Intas Pharmaceuticals
- Interquim
- Ipca Laboratories
- i-Pharmaceuticals
- Isochem (acquired by PMC Group)
- Iwaki Seiyaku Sakura Factory
- JB Chemicals and Pharmaceutical
- Jay Chemicals
- Jadran Galenski Laboratory (JGL)
- J-Star Research
- Jubilant Biosys
- Kalexsyn
- Kamat Pharmatech
- Katsura Chemical
- Kekule Pharma
- Kemwell Biopharma
- Kilitch Drugs
- Kingchem Life Sciences
- Kohlberg & Company
- Kokando
- Kolmar
- Kongo Chemical
- Korten
- KP Pharmaceutical Technology
- Krebs Biochemicals
- Kryptochem Medicament
- Kyoto Pharmaceutical
- Kyowa Pharma Chemical
- Laboratorios Farmacéuticos ROVI
- Laboratorios Inibsa
- Salvat
- Lameplast
- Lamplast
- Laurus Labs
- Lebsa
- Lenus Lifecare
- LGM Pharma
- Lifekyor Pharmaceuticals
- Lloyd Laboratories
- LOBA Feinchemie
- Logos Pharma
- Lomapharm
- Lonza
- Lotus Pharma
- LSNE
- Lubrizol Life Science
- Luitpold Pharmaceuticals
- Lyne Laboratories
- M2i
- Macter
- Madras Pharmaceuticals
- Maiva Pharma
- Makcur Laboratories
- Malladi Drugs & Pharmaceuticals
- Matreya
- Maxtar Bio Genics
- McGuff Pharmaceuticals
- Medical Product Laboratories
- Medichem
- Medilux Laboratories
- Mediwin Pharmaceuticals
- MedPharm
- Mehta API
- Menadiona
- Symeres
- Metrics Contract Services
- Metrochem API
- Micro Labs
- Micro-Sphere
- Mikart
- MINAKEM
- Mipharm
- MSN Laboratories
- Multi Packaging Solutions
- Multi-Pack Solutions
- Murty Pharmaceuticals
- Nagase Medicals
- Nakoda Chemicals
- Nanjing Pharmatechs
- Natco Pharma
- Nautic Partners
- Nectar Lifesciences
- Neiss Labs
- Nephron Pharmaceutuicals
- NerPharma
- Neuland Laboratories
- Nexgen Pharma (acquired by LGM Pharma)
- Nextar Chempharma Solutions
- NextPharma
- Nippon Rika Technologies
- Nipro Pharma
- Nitto Avecia
- Nivon Specialties
- Norac Pharma
- Norchim
- Novacap
- NovaQuest
- Novartis
- Novasep
- Novo Holdings
- Nutragen Pharma
- Nutraplus India
- Nvron Life Science
- Oakwood Labs
- Oasis Laboratories
- Oceanic Pharmachem
- Olainfarm
- Olic (Thailand)
- Olon
- Oman Pharmaceutical Products
- Oncotec Pharma Produktion
- Orbis Biosciences
- Orchid Pharma
- Orient Pharma
- Orion
- Orofino Pharmaceuticals
- Otsuka Pharmaceutical
- Panacea Biotec
- PannonPharma
- Parabolic Drugs
- Patheon
- PCI Pharma Services
- Pegasus Farmaco
- Penmix
- Perrigo
- Pfizer
- Pfizer CentreOne
- Pharma Stulln
- PharmAgra Labs
- Pharma-Q
- Pharmascience
- Pharmasol
- PharmaSynth
- PharmaZell
- Pharmed Healthcare
- Pharmer
- Phekolong Pharmaceuticals (Laurus Labs)
- Phytex Australia
- Phyton Biotech
- Pidolma Healthcare
- Pharmaceutical Institute of India (Pii)
- Pillar5 Pharma
- PIQ-Pharma
- Piramal Pharma
- PiSA Farmaceutica
- Pisgah Labs (acquired by Ipca Laboratories)
- i Group
- PMRS
- Polfa Tarchomin
- Polpharma
- Poly Pharmaceuticals
- PolyPeptide
- Porton Fine Chemicals
- Permira
- PrimaPharma
- Prisha Healthcare
- Priyans Drugs
- Procaps
- Procos
- Pyramid Pharma
- Qualiphar-Gifrer
- Quality Chemical Laboratories
- Quay Pharmaceuticals
- Que Pharma
- Quotient Sciences
- Radico Remedies
- Rafarm
- Raybow PharmScience
- Recipharm
- Redwing Pharma
- Regis Technologies
- Remington Pharmaceuticals
- Olon Ricerca Biosciences
- Ritedose
- Rivopharm
- RL Fine Chem
- Robinson Brothers
- Rommelag
- Rompharm
- Rottendorf Pharma
- Rubicon Research
- Rusan Pharma
- S M Pharmaceuticals
- Sai Life Sciences
- Sandoz
- Sanico
- Sannova Biotech
- Sanochemia Pharmazeutika
- Santen Pharmaceutical
- Sanwa Kagaku Kenkyusho
- Sarvodaya Drugs and Pharmaceuticals
- Sarvotham Care
- Sato Yakuhin Kogyo
- SAVA Healthcare
- Savior Lifetec
- SCI Pharmatech
- ScinoPharm
- Seacross Pharmaceuticals
- Seikagaku
- Sekisui Medical
- Selvok Pharmaceutical
- Sentiss Pharma
- Seqens
- Shandong Xinhua Pharmaceutical
- Sharon Bio-Medicine
- Shilpa Medicare
- Siegfried
- Sigmapharma Laboratories
- Sinopharm
- Sirio Pharma
- SK biotek
- SK Holdings
- Smruthi Organics
- SMS Pharmaceuticals
- Societa Italiana Medicinali Scandicci
- Softgel Healthcare
- Solara Active Pharma Sciences
- Solopharm
- Sovereign Pharmaceuticals
- SPC Lifesciences
- Square Pharmaceuticals
- Stason Pharmaceutical
- Stelis Biopharma
- Stericon Pharma
- Sterling Pharma Solutions
- Sterling Pharmaceuticals
- Sunrise Pharmaceutical
- Sunways
- Supriya LifeScience
- Suven Life Sciences
- Swiss Pharma
- Symed Labs
- Synbias Pharma
- Syncom Healthcare
- Syngene
- Synthokem Labs
- Sypharma
- Syntegon
- Tahira Industries
- Tai Heng Industry
- Taiyo Pharma Tech
- Tatchempharmpreparaty
- Tedor Pharma
- Teika Pharmaceutical
- Tekni-Plex
- Teligent
- Teva Pharmaceuticals
- Theon Pharmaceuticals
- Thermo Fisher Scientific
- Titan Pharmaceuticals
- Toa Pharmaceutical
- Tolmar
- Torrent Pharmaceuticals
- FUJIFILM Toyama Chemical
- TriPharm Services (acquired by Alcami)
- Trugen Pharma
- Tyger Scientific
- UBE Industries
- Ultratech India
- Unibiotech Formulations
- Unichem Laboratories
- Unimark Remedies
- Unison Chemical Works
- UPM Pharmaceutical
- Uquifa
- Ursapharm Arzneimittel
- US Pharma Lab
- USV
- Vanamali Organics (acquired by Wavelength Pharmaceuticals)
- Vetter Pharma
- Vinkem Labs
- Vital Healthcare
- VUAB Pharma (SAFICHEM)
- Wanbury
- Wavelength Pharmaceutical
- WCCT Global
- WDPrx- Woodfield Pharmaceutical
- WellSpring Pharmaceuticals
- West Pharmaceutical Services
- WestRock
- Wilmington PharmaTech
- Windlas Healthcare
- Wintac
- Wisdom Pharmaceuticals
- Wockhardt
- WuXi AppTec
- Xellia Pharmaceuticals
- Xi'an Lijun Pharmaceutical
- Xttrium Laboratories
- YaoPharma
- Yash Pharma Laboratories
- Yegna Manojavam Drugs and Chemicals (acquired by PMC Group)
- Yuhan
- Yung Zip Chemical
- Zach Systems (Zambon)
- ZCL Chemicals (acquired by Advent International)
- Zenith Healthcare
- Zenlabs
- ZheJiang Apeloa JiaYuan Pharmaceutical
- Zhejiang Changming Pharmaceutical
- Zhejiang Cheng Yi Pharmaceutical
- Zhejiang Excel Pharmaceutical
- Zhejiang Hisun Pharmaceutical
- Zhejiang Huahai Pharmaceutical
Methodology
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