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Microarray Markets


Description: A microarray is an arrangement of miniaturized test sites or "spots" on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules--usually DNA or protein--which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample. Microarrays are often also known as "biochips".

The purpose of this report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include:

1) expression profiling;
2) serum-based diagnostics;
3) protein-protein binding assays;
4) drug-target binding; and
5) receptor epitope binding.

It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma. It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the companys market position.

The five main objectives of this analysis are:

- Identifying viable technology drivers through a comprehensive look at platform technologies for DNA and protein arrays, including, probe-based nucleic acid assays, microarrays and sequencing.
- Obtaining a complete understanding of the chief DNA and protein array tests from their basic principles to their applications.
- Discovering feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, focusing on the biggest and expanding markets.
- Focusing on global industry development through an in-depth analysis of the major world markets for DNA and protein array technology, including growth forecasts.
- Present market figures regarding the current value of the microarray market, projections and growth rates. The source of this information is the most current data derived from the global diagnostic industry.

By purchasing this report, you will have:

- An understanding of the most exciting microarray market segments, current and future.
- The latest information on leading products and research and development (R&D) initiatives.
- Familiarity with recent developments and their effects on selected markets.
- Knowledge of the microarray market as an area of growth, research and investment.

Key questions answered in this report:

- How can microarray tools and technologies facilitate drug discovery, design and development?
- What are the main types of array technologies that are currently available?
- Who are the current key players in this marketplace?
- Which microarray market areas have the greatest potential for growth?
- What is the current state of the microarray market?
- Which biotechnology and pharmaceutical companies are investing in microarray solutions?
- What are the main microarray business strategies adopted by leading companies?
- What are the benefits of microarray technology platforms?

This report contains:

- Detailed analysis of recent trends in the microarray marketplace.
- In-depth profiles of 16 leading companies with microarray tools and technologies.
- A five-year forecast for the microarray market in the biotechnology and pharmaceutical industries.
- Views and principles on the microarray industry from leading industry experts.
- Analysis of potential microarray applications in the life science sector.
- Market predictions and trends analysis concerning U.S. expenditure on array solutions.
- Projections for future applications of microarrays in drug discovery, from the industrys R&D perspective.
- Analysis of commercial microarray business strategies.
- The latest news and developments in the microarray marketplace.
- A comprehensive overview and insight into microarray business strategies.


Contents: 1. Overview 4
1.1 Statement of Report 4
1.2 About This Report 4
1.3 Scope of the Report 5
1.4 Objectives 6
1.5 Methodology 6
1.6 Executive Summary 7

2. Overview of Microarrays 9
2.1 History of Microarrays 9
2.2 Genomics and Proteomics 10
2.2.1 Genetic Variability and Disease 11
2.3 General Theory of Microarrays 11
2.4 DNA Microarrays 12
2.5 Protein Microarrays 14
2.6 Tissue Microarrays 15

3. DNA Microarrays 17
3.1 Advantages and Drivers 17
3.2 Limitations and Barriers to Commercialization 18
3.3 DNA Microarray Technology Platforms 19
3.3.1 Reasons Why Researchers Utilize DNA Microarrays 23
3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 23
3.4 Key Attributes of DNA Microarray Software 24
3.5 Applications 24
3.6 Future Directions for DNA Microarray Technology 29
3.6.1 High-Throughput Array Technology 29
3.6.2 Emerging Microarray Trends 31
3.6.3 Emerging Microarray Applications 31
3.6.4 Key Points for Developing Microarray Based Applications 32
4. Protein Microarrays 33
4.1 Critical Factors for Microarray Content 33
4.2 Key Findings on Use of Microarrays 33
4.3 Advantages and Drivers 34
4.4 Limitations and Barriers to Commercialization 36
4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 38
4.6 Reasons Why Researchers Utilize Protein Microarrays 39
4.7 Factors for Adoption of Protein Microarrays Technology 39
4.8 Top Suppliers of Protein Microarray Slides and Products 40
4.9 Factors that Influence Sale Decisions 40
4.10 Future Innovations in Protein Microarray Technology 40

5. Current DNA Microarrays 41
5.1 Key Players 41
5.2 High Growth Applications 43
5.2.1 Microarray-Based Commercial Genotyping Activity 43
5.2.2 Location Analysis 43
5.3 Future Innovations in DNA Microarray Technology 43

6. Current Protein Microarrays 45
6.1 Protein Profiling Microarrays-Antibody Arrays 45
6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 47
6.3 Multiplex Sandwich Microarrays-Planar 48
6.4 Multiplex Sandwich Immunoassays-Bead Based 50
6.5 Microarrays for Protein Function Studies 52
6.6 High Growth Applications 54
6.6.1 Cytokine Arrays 54
6.6.2 Whole Proteome Arrays 54
6.6.3 Microarray-Based Commercial Genotyping Activity 54
6.6.3.1 Microarray-Based Genotyping Applications 54
6.6.3.2 Microbial Applications 55
6.6.3.3 The Market for Microbial Genotyping Products 56
6.6.3.4 Comparative Genomic Hybridization 56
6.6.4 ChIP-on-Chip Analysis 57

7. Technology 59
7.1 Production of Microarrays 59
7.2 2-D Versus 3-D Technology 61
7.3 Substrates and Surface Chemistries 61
7.4 Detection Methods 63
7.5 Instruments 63
7.6 Data Management and Informatics in Gene Expression 64

8. Applications 65
8.1 DNA Microarrays in Gene Expression 65
8.2 DNA Microarrays in SNP Analysis 68
8.3 DNA Microarrays in Cancer 69
8.4 Protein Expression 69
8.4.1 Cytokine Applications 70
8.4.2 Protein Function 70
8.4.3 Protein-Protein Interactions 71
8.5 Target /Biomarker Discovery 71
8.6 Drug Discovery and Development (Gene and Protein Microarrays) 72
8.7 Clinical Diagnostics (Gene and Protein Microarrays) 72
8.8 RNA Microarrays 73
8.9 Oligo Microarrays 73
8.10 Yeast Microarrays 74
8.11 Antibody Arrays 74

9. The Commercial Opportunity for Microarrays 75
9.1 Market Drivers for Microarrays 75
9.2 Market Restraints for Microarrays 75
9.3 Key Players 76
9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 79
9.5 Marketing and Distribution 81
9.6 Protein Arrays Market Analysis 82
9.7 Genes Associated with Major Diseases 83
9.8 Software and Data Analysis 83
9.8.1 Supplier of DNA Microarray Analysis Software 84
9.8.2 Satisfaction with Software Features 84
9.8.3 Satisfaction with Software 84
9.8.4 Supplier Factors in Software Purchase Decision 84
9.8.5 Suppliers Role in Improving Data Sharing for DNA Microarrays 84

10. Legal Aspects of Commercialization of Protein Arrays 85

11. Company Profiles 87

Appendix 1: Microarray Milestones 124


LIST OF FIGURES

Figure 5.1: Company Market Shares 41
Figure 8.1: Overall Market Size by Application, 2005 66
Figure 8.2: Source of Variation in Microarray Data 73


LIST OF TABLES

Table 3.1: Source of DNA Microarrays in Research Use 17
Table 3.2: Microarray Market Drivers 17
Table 3.3: Microarray Market Barriers 18
Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 18
Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 20
Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available 21
Table 3.7: Microarray Applications 24
Table 3.8: List of DNA Array Manufacturers 26
Table 4.1: Critical Factors for Microarray Content 33
Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 40
Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 40
Table 4.4: Top Suppliers of Protein Microarray Readers 40
Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005 42
Table 5.2: Affymetrix Total Product Sales, 1999-2005 42
Table 5.3: Affymetrix Instrument Sales, 2000-2005 42
Table 6.1: Microarray Genetic Testing 54
Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 57
Table 8.1: Applications of Biochips by Class 65
Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 66
Table 8.3: HTS Microarray Market Size Projections, 2005-2011 66
Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 67
Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 67
Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 67
Table 9.1: Market Share of Microarray Products, 2004 76
Table 9.2: Affymetrix Product Sales 77
Table 9.3: Agilents Net Revenue by Business Segment, 2002, 2003 and 2004 77
Table 9.4: Leading Microarray Companies 78
Table 9.5: Worldwide Microarray Market Size, 2004-2011 79
Table 9.6: Microarray Market Share by Technology Type 79
Table 9.7: DNA Microarray U.S. Market Size, 2005-2011 80
Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011 80
Table 9.9: Biochip Market by Usage, 2003 and 2007 80




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