Organic Synthesis Using Biocatalysis

Table of Contents

CHAPTER 1 Introduction, Types of Reactions, and

Sources of Biocatalysts

Animesh Goswami, Jon D. Stewart

CHAPTER 2 Practical and Engineering Aspects of Running Enzyme

Reactions

Harald Gröger

CHAPTER 3 Biocatalysis in Organic Solvents, Supercritical

Fluids and Ionic Liquids

Chen Cao, Tomoko Matsuda

CHAPTER 4 Enzyme Immobilization for Organic Synthesis

Melissa L.E. Gutarra, Leandro S.M. Miranda,

Rodrigo O.M.A. de Souza

CHAPTER 5 Hydrolysis and Formation of Carboxylic Acid

and Alcohol Derivatives

Romas Kazlauskas

CHAPTER 6 Modern Biocatalytic Ketone Reduction

Thomas S. Moody, J. David Rozzell

CHAPTER 7 Organic Synthesis with Amino Acid Dehydrogenases,

Transaminases, Amine Oxidases, and Amine

Dehydrogenases

Samantha K. Au, Jonathan Groover, Brent D. Feske,

Andreas S. Bommarius

CHAPTER 8 Biocatalysis for Organic Chemists: Hydroxylations

Laila Roper, Gideon Grogan

CHAPTER 9 Miscellaneous Key Non-C_C Bond Forming Enzyme

Reactions.......................................................................243

Florian Rudroff, Michael J. Fink, Marko D. Mihovilovic

CHAPTER 10 Enzymatic C_C Bond Formation .....................................285

Pere Clapés

CHAPTER 11 Applications of Biocatalysis for Pharmaceuticals

and Chemicals ................................................................339

Ramesh N. Patel

CHAPTER 12 Future of Biocatalysis in the Synthesis of Organic

Compounds ....................................................................413

Animesh Goswami, Jon D. Stewart

Authors

Animesh Goswami Chemical Development, Bristol-Myers Squibb, New Brunswick, NJ, USA. Dr. Animesh Goswami has more than 25 years of industrial experience and is an expert in the industrial application of biocatalysis for the synthesis of organic compounds. He joined Bristol-Myers Squibb in 1998 and is currently a research fellow leading the Biocatalysis group of Chemical Development department. Before joining Bristol-Myers Squibb, he worked in research and development of Rhone-Poulenc in USA for eleven years. He is author/co-author of forty five publications and fifteen patents and patent applications. He has published extensively and has given numerous invited lecturers in national and international meetings in the area of biocatalysis. Dr. Goswami earned his Ph.D from the University of North Bengal in India and has conducted post-doctoral studies at Arizona State University and University of Iowa in USA. He is a member of the American Chemical Society and the Society for Industrial Microbiology and Biotechnology. Jon Stewart University of Florida, Gainesville, FL, USA. Dr. Jon D. Stewart has led his academic research group at the University of Florida since joining the department in 1994 as an Assistant Professor. He was promoted to Professor of Chemistry in 2006 and also has affiliate appointments in the Departments of Biochemistry & Molecular Biology and Biomedical Engineering. His research has included a number of topics in biocatalysis including Baeyer-Villiger monooxygenases, nicotinamide-dependent carbonyl reductases with a current emphasis on alkene reductases. He has authored or co-authored 100 research publications and has given numerous invited lectures at meetings and companies. He has served as an editor for the Journal of Molecular Catalysis B: Enzymatic since 2003. Dr. Stewart earned B.S. and M.S. degrees from Bucknell University, his Ph.D. from Cornell University and was a Helen Hay Whitney Postdoctoral Fellow at Penn State University.